Sjögren's Syndrome Models

Sjögren's syndrome(SS) is an autoimmune disorder that primarily affects the exocrine glands. It particularly targets the salivary and lacrimal glands, resulting in dry mouth (xerostomia) and dry eyes (xerophthalmia). Sjögren's syndrome can also involve other organs and systems, causing various symptoms such as joint pain, fatigue, and difficulties in swallowing.

1. Sjögren’s syndrome model

Validation data

Saliva volume decreased in Salivary gland protein induced mice.

Salivary gland index increased on day63 in salivary gland protein induced mice.

Spleen weight index Increased on day 35 in salivary gland protein induced mice.

Lymphocytic infiltratio increased in submandibular gland of salivary gland protein induced mice.

CD3+ T cell infiltration increased in submandibular gland of salivary gland protein induced mice.