Genetically Humanized Mice

1. Extensive Portfolio with Ready-to-Ship Inventory We offer a comprehensive catalog of humanized models spanning multiple disease areas. Popular models are maintained as ready-to-ship inventory to ensure rapid delivery. 2. Comprehensive Coverage of Single and Multi-Gene Designs Our portfolio includes complete single-gene and multi-gene combinatorial humanized strains, eliminating the need for complex cross-breeding and saving significant time and experimental costs. 3. Rigorously Validated Models Human genes are stably expressed with uniform phenotypes and minimal batch-to-batch variation, ensuring high reproducibility and reliable data integrity. 4. Full Customization Capabilities We support precise point knock-ins/knock-outs, full-length/ectodomain humanization, specific point mutations, and multi-gene stacking. Our expert team provides end-to-end technical support throughout the process. 5. Integrated Preclinical Efficacy Evaluation Platform We provide one-stop services encompassing model supply, drug screening, efficacy assessment, and mechanistic studies. This closed-loop system eliminates the need for cross-institutional collaboration, significantly shortening your R&D timeline. 6. Mature Breeding and Quality Control System Utilizing standardized breeding protocols and full-process quality control, we guarantee genetically pure backgrounds and stable passage inheritance, ensuring consistent and reliable experimental results.

1. Drugs directly target UTR regulatory elements Nucleic acid drugs including siRNA, antisense oligonucleotides (ASO) and miRNA modulators directly act on the UTR region of mRNA (especially 3′UTR) to inhibit translation or trigger RNA degradation. Given the substantial sequence divergence of UTRs between humans and mice, conventional models with only coding region (CDS) humanization fail to be recognized by human-specific nucleic acid drugs. Consequently, concurrent replacement of the human UTR is mandatory to ensure authentic and reliable efficacy evaluation. 2. Efficacy and Toxicity Studies Dependent on Transcript Stability The pharmacological activity and toxicological profiles of certain drugs are governed by 3′UTR-mediated mRNA stability (e.g., the decay mechanism of transcripts containing AU-rich elements, or AREs). Retaining the murine UTR can lead to aberrant degradation or accumulation of the humanized mRNA in vivo, preventing the recapitulation of authentic human protein expression levels and downstream signaling pathways. This discrepancy inevitably results in distorted efficacy readouts and compromised toxicity assessments.