Sjögren’s Syndrome (SS)

Sjögren's syndrome (SS) is an autoimmune disorder that primarily affects the exocrine glands. It particularly targets the salivary and lacrimal glands, resulting in dry mouth (xerostomia) and dry eyes (xerophthalmia). Sjögren's can also involve other organs and systems, causing various symptoms such as joint pain, fatigue, and difficulties in swallowing.

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Our Advantages

Comprehensive Model Portfolio

We provide a diverse collection of Sjögren’s model types, including spontaneous models and induced models

Diverse Animal Models with Distinct Pathogenic Mechanisms

Sjögren’s models exhibit clear and diverse pathogenic mechanisms driven by B cells, T cells, or STING pathway activation, rendering them suitable for preclinical studies targeting distinct drug mechanisms of action (MoAs).

Model Library

Case Studies

Case Studies & Validation Data

Salivary gland protein induced SS model

Phenotypic manifestations of salivary gland protein induced SS model

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Panel A Study design of the salivary gland protein-induced SS mouse model.

Panel B The level of anti-dsDNA IgG was elevated in the modeling group at the endpoint.

Panel C Salivary volume was reduced in the modeling group.

Panel D T-cell infiltration was increased in the submandibular gland.

Panel E Spleen and salivary gland indices were increased in the modeling group.

Statistical analysis was performed using one‑way ANOVA, and all data are presented as mean ± SEM. *p<0.05, **p<0.01, ***p<0.001，****p<0.0001

STING agonist induced SS model

Phenotypic manifestations of STING agonist induced SS model

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Panel A Study design of STING agonist induced SS model.

Panel B Serum anti-ANA and anti-dsDNA IgG levels were elevated in the model group, while the saliva flow rate was decreased in the model group.

Panel C Cytokine levels of IFN-β, IL-6, TNF-α and Mx1 were elevated in the model group.

Panel D Immune cell populations in the spleen were elevated on Day 28 in the model group.

Statistical analysis was performed using one‑way ANOVA, and all data are presented as mean ± SEM. *p<0.05, **p<0.01

NODShiLtJGpt spontaneous SS mice model

Phenotypic manifestations of NODShiLtJGpt spontaneous SS model

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Panel A NOD mice exhibited reduced salivary flow rate and tear production compared with the BALB/c strain. Serum levels of anti-SSA antibody, anti-dsDNA IgG, and total IgG were elevated in NOD mice relative to BALB/c mice.

Panel B Monocytes, CD3⁺ cells, plasma cells, Th1, Th17 and Treg cells were increased in 22-week-old NOD mice compared with BALB/c mice.

Panel C HE histological score of the submandibular gland was increased in 22-week-old NOD mice

Statistical analysis was performed using one‑way ANOVA, and all data are presented as mean ± SEM. *p<0.05, **p<0.01, ***p<0.001，****p<0.0001

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