Core Research Strains

Both are substrains of C57BL/6, with key differences: C57BL/6JGpt is the more classic substrain, widely used in immunology, oncology, and neuroscience, with extensive published data; C57BL/6NGpt is derived from the N substrain, with differences at certain genetic loci (e.g., Nnt, Pde6b) compared to the J substrain, making it more suitable for metabolic, cardiovascular, and ophthalmic research. Selection advice: Choose C57BL/6JGpt if you need to compare with existing literature based on the J substrain; Choose C57BL/6NGpt if your study focuses on metabolism (e.g., Nnt deficiency effects) or requires alignment with international N-substrain data.

C57BL/6JGpt, BALB/cJGpt, ICR, etc., are commonly used in immunology, oncology, genetics, and behavioral studies; NOD/ShiLtJGpt is suitable for type 1 diabetes and autoimmune disease research; A/JGpt, DBA/1JGpt are often used in inflammation and arthritis models.