Disease Mice

High physiological concordance with human aging: With a natural lifespan of approximately 24 to 30 months, their functional decline closely mirrors human aging. Detailed, standardized physiological phenotypic data are available, covering the core hallmarks of aging. Homozygous genetic background for high experimental reproducibility: As a classic inbred strain, C57BL/6JGpt features a highly homozygous genetic background with minimal inter-individual and inter-batch variation. This minimizes genetic confounding, providing a highly stable foundation for studying the complex, polygenic processes of aging. Specialized “non-breeder” aging strategy designed for research: All aged mice are maintained as non-breeders (virgins) throughout their lifespan, rather than being retired breeders. This eliminates the physiological and reproductive stress associated with gestation and lactation, ensuring that the mice represent a state of pure, natural aging. Comprehensive quality assurance and reliable supply: Housed in SPF (specific pathogen-free) facilities, these mice undergo high-standard health monitoring and rigorous genetic quality control. Mice aged 52 weeks and older are available off-the-shelf with abundant inventory and precise age tracking down to the exact week or day.

Aged mice serve as ideal models for studying natural aging. Their applications are highly diverse, spanning numerous research fields including the basic biology of a healthy lifespan, bone density and motor function, age-related visual and auditory impairments, immunology and oncology, cognitive and neurodegenerative diseases, metabolic disorders, mechanisms of aging and therapeutic interventions, as well as reproductive endocrine disorders. Aged mice from GemPharmatech have already empowered researchers to achieve breakthrough discoveries published in top-tier journals across several cutting-edge fields—such as sarcopenia, immunosenescence and cancer immunotherapy, and post-stroke immune repair—fully demonstrating their immense value in age-related research.