Duchenne Muscular Dystrophy (DMD)

Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder characterized by progressive muscle weakness and degenerative neurological symptoms, predominantly affecting males due to a mutation in the DMD gene, which encodes dystrophin — a critical protein located in the muscle sarcolemma and plays a role in maintaining muscle stability. Exon deletion is the most common mutation, accounting for 55–65% of cases, and are a primary target for emerging therapies.

50+
Mouse Models Related to Neurological Diseases
500+
Studies Completed
10+
ND-Enabling Studies

Advantages

Our Advantages

Comprehensive DMD Model Portfolio

Our DMD models cover multiple mutation types — full knockout, point mutation, and exon deletion — reflecting the genetic heterogeneity of human DMD and enabling exon-skipping and gene therapy evaluation.

Multi-Endpoint Phenotypic Assessment

From motor function (rotarod, grip strength) to serum CK levels and histopathology, our models support thorough characterization of disease progression and therapeutic response.

Regulatory-Ready Study Design

From model selection to experimental endpoints, our team works closely with sponsors to tailor study protocols that align with specific research goals and regulatory requirements for DMD disease therapies.

Model Library

Case Studies

Case Studies & Validation Data

Dmd Del52 Motor Dysfunction & CK Study

B6-DMD Del52 Mice Exhibit Elevated CK Levels, Progressively Declining Motor Function, and Muscle Atrophy

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B6-DMD Del52 Mice Exhibit Elevated CK Levels, Progressively Declining Motor Function, and Muscle Atrophy

Panel A and B: Mice exhibited motor dysfunction from 6 weeks of age.

All data represented as mean ± SEM. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001, two-way ANOVA.

Panel C and D: B6-DMD Del52 mice exhibited elevated serum CK levels and (D) muscle atrophy (H&E stain) at 6 weeks of age. Blue arrow, muscle fiber atrophy; green arrow, muscle fiber necrosis; purple arrow, nuclear translocation; brown arrow, neutrophils; white arrow, macrophages. Scale bar: 50 μm.

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