head-icon1.svgMeet us at an upcoming event
head-icon2.svgIn Stock. Ready to Ship
languageEN
languageEN
icon-arrow-g
counsellingContact Us
languageEN
languageEN
icon-arrow-g

小鼠banner.jpg小鼠banner.jpg

State-Of-The-Art Genetic Engineering for Mice and Rats

Request a Quotearrow-right-warrow-right-g
  • yimg10.svg
    AAALAC Accredited
  • gem2.png
    Animal Welfare Compliant
  • 22,000+
    Custom Models Successfully Engineered
  • 8,000+
    Annual Model Creation Capability
  • 6 Months
    Delivery for Standard Gene Editing Projects (F1)

Why Us

Why Choose Gempharmatech For Custom Model Generation?

Industry-leading expertise combined with state-of-the-art facilities.

GemPharmatech is the world's leading expert in custom model generation. With the experience of developing over 22,000 genetically engineered mouse models, we maintain the world's largest repository of strains. Selecting the right model is critical to research success. When existing models fail to reflect the biological mechanism of interest — or when scientific, translational, or budgetary considerations demand a tailored approach — custom model generation offers a precise, cost-effective solution. Here's why leading research teams partner with GemPharmatech:

IMG_3253 (1).JPG

mask

Scalable Platform

Extensive experience gained from the "Knockout All Project," continuous donor production, optimized targeting design and screening processes.

01

mask

Optimized Strategy Design

Proprietary algorithm for automated strategy design and optimization of KO, cKO, large KI and point mutation models.

02

mask

Expertise in Complex Editing

Proven capability in large-fragment knock-ins, conditional knockouts, point mutations, and genetic humanization.

03

mask

Experienced Specialists

Core project managers and research technicians with 15+ years of experience in custom allele design and model production.

04

Global Comparison

Comparison with other Global Customized Model Service Providers

zimg66.svg Aspectzimg65.svg GemPharmatech Conventional Providers
01Delivery Speedcheck 6-8 months for gene edited F1 mice9-12+ months
02Cost Efficiencycheck Competitive pricing due to scaled production & stable qualityHigher operations costs
03Genetic Backgroundscheck Deep expertise across multiple strain backgroundsUsually background strain limited and extended timeline for special backgrounds
04Strategy Designcheck Rapid design & quote delivery within 2-3 business days enabled by propriety algorithmTypically slower response to inquiries
05Intellectual Property Flexibilitycheck Full client ownership of IPMay involve additional restrictions
06Project Managementcheck One-on-one routine reports and milestone progress updatesLess frequent communication throughout the project
07Complex Engineering Capacitycheck Nuclease-based editing: 16 kb+ KI and 500 kb+ deletion ESC-based targeting: 300 kb BAC-Tg: 300 kbLimited for large fragment integration or deletions
08Delivery Guaranteecheck Genotype guaranteed (>99% on-time delivery rate)Varies (often limited by maximum number of injected embryos)

Technical

Comparison of Commonly-Used Model Generation Methods

TechniqueNuclease-based Gene EditingESC based targeted mutagenesisTransgene
Targeted modificationYes (HDR based DNA DSB repair)Yes (Homologous recombination)No (Random integration)
Genetic backgroundUnrestrictedLimited optionsUnrestricted
CostLowHighLow (High for stable line generation)
Lead time6-8 months（for F1 heterozygotes）9-12 months (for F1 heterozygotes)3-4 months (for F0 founders)
Integration sizeFlexible (less effective for large fragments)Flexible (up to >100 kb)Flexible (up to >100 kb: BAC-Tg)

Timeline

When Will I Receive The Mice?

Our streamlined workflow ensures efficient delivery of your custom models

Ready to Start Your Project?
Contact Usarrow-right-warrow-right-g

Quality

Quality Control

End-to-End Quality Control

Quality

check

Construction PhaseF0 founders and F1 mice validated by PCR, Sanger sequencing, as well as random insertion and integrity analysis. Southern blot and off-target analysis available.

check

Compliance AssuranceAll operations conducted in AAALAC-accredited facilities adhering to international animal welfare standards.

check

Delivery PhaseComprehensive genotyping report and animal health report.
Learn More About Qualityarrow-right-warrow-right-g

zimg18.png

FAQ

Frequently Asked Questions

What types of genetic engineering models can Gempharmatech provide?

Gempharmatech's model customization service enables precise genetic modifications including gene knockout (KO), conditional knockout (cKO or "floxed") alleles, knock-in at endogenous loci and safe harbors (including conditional knock-ins and conditional point mutations), point mutations, genetic humanizations and transgenesis. We also offer a vast collection of already generated gene knockout and floxed strains on C57BL/6JGpt background as ready-to-license products; please refer to our KOAP model library.

Can I generate custom models based on specific genetic backgrounds?

Yes. We generate models on C57BL/6J, BALB/c, BALB/c-Nude, NOD-Scid, NCG, C57BL/6N, BKS-DB, 129, C3H, FVB, B6J-Apoe KO, ICR, SD, and other commonly used strain backgrounds. Additional strains can be utilized upon request. Novel models can also be generated on your own specific strain if animals can be transferred to our facility and undergo SPF decontamination.

How many individuals will I receive upon delivery?

Generally, 3-5 heterozygous F1 of mixed sex will be provided for shipment in each genome editing project. For transgenic models, 3-5 F0 founders will be provided. If you require a larger number of deliverable animals, specific genotypes, sex ratio, or breeding with other strains, please consult with us and take advantage of our integrated custom breeding services.

How does GemPharmatech minimize off-target effects and random integrations during genome modifications?

We use our proprietary target site design and screening algorithm and rationale based on execution of >100,000 targeting projects to optimize the specificity and efficiency of the target site and minimize off-target editing potential. We also perform strict quality control analysis to exclude the founders and F1 individuals with undesired random donor insertions and tandem insertion repeats to ensure the delivery of the animals with correct genotypes. Predicted potential off-target sites of concern can also be screened.

How does GemPharmatech ensure animal quality? Does the genetic information of the inbred and outbred colonies in GemPharmatech differ significantly from the other major vendors?

We maintain state-of-the-art, AAALAC-accredited SPF animal facilities and our operational guidelines follow international animal welfare and health standards. We adhere to the 3-level breeding system, regular foundation colony turnover and annual genetic monitoring to monitor drift and ensure the genetic integrity of our inbred and outbred strains.

Explore

Recommended for You

Courses, services, and resources to accelerate your research

Browse All Coursesarrow-right-warrow-right-g

Message

Send Us a Message

Fill out the form below and our team will get back to you within 24 hours.

First Name
Last Name
Organization
Email
Country/Region
Select Country/Region
State/Province
City
Area of interest
Select Area of Interest
Research Focus
How did you hear about us
Select a source
Leave us a message
Reset
Submitarrowarrow
On This Page
  • Why Choose Us
  • Global Comparison
  • Technical
  • Success Stories
  • Timeline
  • Quality
  • FAQ
  • Explore
  • Message
Published Articles
Moreicon-arrow-g
Blogs
Advancing Antifungal Drug Development with Preclinical Fungal Infection Platform
Mar 18, 2026
Webinars
Advancing Respiratory Disease Drug Development: A Comprehensive Mouse Platform for Translational Research
Jun 10, 2026

Submit Inquiry

First Name*

Last Name*

Organization*

Email*

Country/Region*

Select Country/Region

State/Province*

City

Area of interest*

Select Area of Interest

Research Focus

Additional Info

Submitarrowarrow

Contact Us

First Name*

Last Name*

Organization*

Email*

Country/Region*

Select Country/Region

State/Province*

City

Area of interest*

Select Area of Interest

Research Focus

How did you hear about us*

Select a source

Leave us a message

Submitarrowarrow

Schedule a Meeting

Let us know which event you're attending and we'd be happy to connect with you.

First Name*

Last Name*

Organization*

Email*

Country/Region*

Select Country/Region

State/Province*

City

Area of interest*

Select Area of Interest

Research Focus

How did you hear about us*

Select a source

Leave us a message

Submitarrowarrow

Download

First Name*

Last Name*

Organization*

Email*

Country/Region*

Select Country/Region

State/Province*

City

Research Focus

Submitarrowarrow

Download

First Name*

Last Name*

Organization*

Email*

Country/Region*

Select Country/Region

State/Province*

City

Research Focus

Submitarrowarrow

Watch On-Demand Webinar

First Name*

Last Name*

Organization*

Email*

Country/Region

Select Country/Region

State/Province*

City

Research Focus

Submitarrowarrow

Newsletter Signup

First Name*

Last Name*

Organization*

Email*

Country/Region*

Select Country/Region

Area of interest*

Select Area of Interest

Research Focus

Submitarrowarrow