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Preclinical ServicesPreclinical Services

Preclinical Services

Accelerate your drug development journey with our integrated preclinical platform. From target validation to IND-enabling studies,we provide end-to-end solutions with industry-leading expertise and quality standards.
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By Platform

End-to-End Preclinical Solutions

Our integrated platform combines cuting-edge technologies with scientific expertise to deliver reliable, reproducible results for your drug development programs.

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In Vitro Screening

Comprehensive cell-based assays for drug screening and mechanism studies, including proliferation apoptosis, and cell cycle analysis.
Preclinical Pathology Services
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Molecular Testing
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In Vitro Services
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 Flow Cytometry Services
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In Vivo Efficacy Evaluation

Robust preclinical efficacy studies using validated animal models across multiple therapeutic areas with high translational value.
Imaging and Analysis
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Behavioral Analysis
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PK/PD Studies

Pharmacokinetic and pharmacodynamic profiling to understand drug absorption, distribution, metabolism, and excretion.
Preclinical PK/PD Services
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By Indication

Browse Disease

Explore our comprehensive collection of animal models organized by therapeutic area. Each category contains validated models for specific disease indications.

Oncology

Oncology

GemPharmatech offers a fully integrated oncology research platform designed to accelerate the discovery and development of innovative cancer therapeutics. With deep expertise across genetically engineered mouse models, humanized mouse models, syngeneic tumor models, CDX/PDX platforms, and immuno-oncology evaluation systems, we provide end-to-end preclinical solutions — from target validation and efficacy assessment to pharmacology and safety evaluation.
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Metabolic Diseases

Metabolic Diseases

GemPharmatech's metabolic disease platform delivers validated animal models and pharmacology services spanning obesity, diabetes, MASH, diabetic nephropathy, and related disorders, and is purpose-built to accelerate preclinical drug development.
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Inflammatory and Autoimmune Diseases

Inflammatory and Autoimmune Diseases

GemPharmatech's autoimmune and inflammatory disease platform spans rheumatology, dermatology, digestive, renal, respiratory, and neurological models — delivering the research tools and pharmacology services needed to advance therapeutic development across every indication.
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Cardiovascular Diseases

Cardiovascular Diseases

GemPharmatech offers comprehensive preclinical models spanning the full cardiovascular-kidney-metabolic disease spectrum — from lipid dysregulation to advanced heart failure — supporting early-stage drug discovery through therapeutic validation.
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Neurological Diseases

Neurological Diseases

Neurological disorders are a broad category of medical conditions affecting the nervous system, characterized by damage or dysfunction in neurons, including axons, dendrites, synapses, and associated glial cells throughout the nervous system. GemPharmatech offers services and models for several types of neurological disorders including neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), as well as chronic pain and psychiatric disorders (e.g., depression, anxiety disorders, schizophrenia).
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Respiratory Diseases

Respiratory Diseases

Respiratory diseases encompass a broad range of conditions — from acute infections to chronic inflammatory disorders — affecting the airways, lungs, and surrounding tissues. Despite their diversity in mechanism and progression, they share a common and urgent need for effective therapies. GemPharmatech's respiratory platform provides validated models and integrated pharmacology services spanning multiple indications, designed to support every stage of preclinical drug development.
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Infectious Diseases

Infectious Diseases

Infectious diseases remain a persistent threat to global public health, and mouse models have become indispensable tools for combating them. GemPharmatech's models and services enable researchers to study infection mechanisms, characterize immune responses, and evaluate therapeutic efficacy preclinically to accelerate targeted drug discovery.
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Rare Disease

Rare Disease

Rare diseases present some of the most complex and unmet challenges in modern medicine. GemPharmatech's rare disease model portfolio and Knock-out All Project (KOAP) library encompasses a broad panel of knockout (KO) mouse models, each engineered to replicate a gene deletion or mutation underlying a wide spectrum of genetic disorders.
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Gut Microbiota Research Service

Gut Microbiota Research Service

A growing body of research shows that gut microbiota plays a regulatory role in tumors, autoimmune disorders, metabolic diseases, neurological disorders, and other disease areas. GemPharmatech offers an integrated platform covering strain screening, germ-free mouse model generation, in vivo pharmacodynamic studies, and in vitro detection and analysis to support gut microbiota research.
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By Modality

Browse Drug Type

Explore our comprehensive collection of animal models organized by therapeutic area. Each category contains validated models for specific disease indications.

ICI

Immune Checkpoint Inhibitors

Immunotherapy has transformed cancer treatment, with immune checkpoint inhibitors (ICIs) at its core. Yet species-specific differences between human and murine immune systems continue to hinder the clinical translation of ICI candidates. To bridge this gap, we offer a comprehensive suite of humanized models built to enable robust preclinical evaluation of ICI efficacy.

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ADC

Antibody-Drug Conjugate

GemPharmatech provides integrated in vitro and in vivo solutions for ADC development, spanning target characterization, efficacy evaluation, pharmacokinetics, tumor distribution, resistance modeling, and combination strategies.

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CAR-T

In Vivo CAR-T Efficacy Evaluation

In vivo CAR-T represents an emerging approach to adoptive cell therapy in which CAR constructs are delivered directly to target immune cells within the body — bypassing the ex vivo manufacturing steps required by conventional CAR-T. By generating cytotoxic CAR effector cells endogenously, this strategy reduces production complexity and broadens potential access compared to patient-derived cell therapies.

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TCE

T-Cell Engager

T-cell engagers (TCEs) represent a compelling class of bispecific molecules designed to redirect cytotoxic T cells to tumor cells, bypassing the need for MHC-mediated antigen presentation. By simultaneously binding a tumor-associated antigen and CD3 on T cells, these molecules form an immunological synapse that drives targeted tumor cell killing — offering a potential solution to key limitations seen with both checkpoint inhibitors and autologous cell therapies. Compared to autologous CAR-T therapies, T-cell engagers offer an off-the-shelf advantage with faster turnaround, lower manufacturing complexity, and scalable production — making them an attractive modality for broader patient access across diverse oncological indications.

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Flagship Platform

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Our proprietary fully-human antibody discovery platform combines genetically humanized mouse models with advanced B cell screening technologies to generate therapeutic antibodies with optimal developability profiles.

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Flagship Platform

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