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Alzheimer’s Disease (AD)Alzheimer’s Disease (AD)

Alzheimer’s Disease (AD)

Alzheimer's disease (AD) is a progressive, irreversible neurodegenerative disorder characterized by memory impairment, cognitive decline, and executive dysfunction often accompanied by language disorders, motor impairment, personality changes, and neuropsychiatric symptoms. GemPharmatech has developed several AD models for the screening and safety evaluation of Alzheimer's disease drugs.
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  • 50+
    Neurological Disease Mouse Models
  • 500+
    Studies Completed
  • 10+
    IND-Enabling Studies
Advantages

Our Advantages

Industry-leading capabilities for Alzheimer’s Disease Research

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Clinically Relevant Models

Our AD models closely mimic human disease progression, including amyloid-beta (Aβ) plaque deposition and Tau protein tangle formation — the two core pathological hallmarks of Alzheimer's disease.

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Comprehensive Assessment

Multi-parameter evaluation including behavioral testing (spatial learning and memory), pathological staining (Aβ, GFAP, IBA1), and biochemical analysis.

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Customizable Study Design

Flexible protocols for acute and chronic AD studies, with options for pharmacological induction and humanized model combinations. Models support evaluation of monoclonal antibodies, small molecule drugs, and BBB transport strategies.

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Model Library

Model Library

AD

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Disease Subtype
Models
AD
FAD4T arrowTransgenic
FAD3T(APP/PS1/Tau) arrowTransgenic
FAD2T(APP/PS1) arrowTransgenic
FAD4T-hTREM2 arrowTransgenic
FAD3T-hTREM2 arrowTransgenic
FAD4T-hAPOE3 arrowTransgenic
FAD4T-hAPOE4 arrowTransgenic
FAD3T-hAPOE3 arrowTransgenic
FAD3T-hAPOE4 arrowTransgenic
FAD3T-hTFRC arrowTransgenic
FAD4T-hTFRC arrowTransgenic
FAD3T-hTFRC/CD98HCTransgenic
FAD4T-hTFRC/CD98HCTransgenic
FAD4T-hIGF1RTransgenic
Case Studies

Case Studies & Validation Data

Trontinemab / Lecanemab Therapeutic Efficacy

Therapeutic Efficacy of Trontinemab / Lecanemab in FAD4T-hTFRC Mouse Model

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Therapeutic Efficacy of Trontinemab / Lecanemab in FAD4T-hTFRC Mouse Model

In FAD4T-hTFRC mice, treatment was initiated at 2.5 months of age. Following 14 weeks of dosing, brain tissues were harvested and subjected to staining for Aβ, GFAP, and IBA1. The results demonstrated that Trontinemab achieved better clearance of cerebral Aβ plaques compared to Lecanemab.

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Trontinemab Therapeutic Efficacy

Therapeutic Efficacy of Trontinemab in FAD3T-hTFRC Mouse Model

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Therapeutic Efficacy of Trontinemab in FAD3T-hTFRC Mouse Model

In FAD3T-hTFRC mice, treatment was initiated at 1 month of age. Following 8 weeks of Trontinemab treatment, the protein expression levels of Aβ40 and Aβ42 in the cortex and hippocampus were significantly reduced.

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All Product

All Product Lines

Model
Status
Strain ID
Details
Inquiry
FAD4T
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T053302
Strain ID
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Details
Apoe-KO
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T001458
Strain ID
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Details
B10-Dmd-KO
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T003035
Strain ID
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Details
FAD2T(APP/PS1)
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T005625
Strain ID
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Details
B6-hSNCA-A53T
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T054329
Strain ID
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Details
B6-hHTT130-N
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T054804
Strain ID
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Details
B6-Dmd Del52
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T049591
Strain ID
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Details
FAD3T(APP/PS1/Tau)
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T049751
Strain ID
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Details
B6-hAPOE3
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T054091
Strain ID
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Details
B6-hAPOE4
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T064965
Strain ID
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Details
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On This Page
  • Advantages
  • Model Library
  • Case Studies
    Trontinemab / Lecanemab Therapeutic Efficacy
    Trontinemab Therapeutic Efficacy
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Preclinical Mouse Models for Reliable ALS Therapeutic Insights
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Advancing Alzheimer's Research at AAIC 2025: Discover GemPharmatech's Cutting-Edge AD Mouse Models
Jul 16, 2025

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