Cardiovascular Diseases

Therapeutic Areas

Disease Categories

Explore our comprehensive database of cardiovascular models categorized by disease.

Heart Failure
Heart failure is a complex clinical syndrome characterized by the heart's inability to pump suffcient blood to meet the body's metabolic demands.
Available Models
Left Coronary Artery Ligation (LAD)
lschemia Reperfusion (MlRl)
Transverse Aortic Constriction (TAC)
Heart Failure with Reduced Ejection Fraction (HFrEF)
HFrEF models generated by surgery or drug induction.
Avilable Models
Myocardial Ischemia Reperfusion Injury (MIRI)
Transverse Aortic Constriction (TAD)
ISO Infusion with Osmotic Pump (ISO)
Heart Failure with Preserved Ejection Fraction (HFpEF)
Comprehensive HFpEF models with comorbidities including obesity, diabetes, hypertension and more.
Available Models
HFD+L-NAME
HFD+Ang II
DHDS+HFD+MLDS (Not Disclosed)
Coronary Heart Disease (CHD)
CHD models recapitulate plaque rupture, myocardial ischemia, and NSTE-ACS, bridging preclinical findings to clinical relevance.
Avilable Models
APOE -/- SR-BIΔCT
LDLR -/- SR-BIΔCT
SR-BIΔCT+AAV-hPCSK9mut
Cardiorenal Syndrome
CKM syndrome describes the interconnected pathophysiology of cardiovascular disease, kidney disease, and metabolic disorders
Available Models
BKS-db+AAV-mREN
Rosa26-hAGT+UNX+STZ+AAV-hREN
Cardiomyopathy (CMP)
CMP models including hypertropic (HCM), arrhythmogenic right ventricular (AVRC), dilated (DCM), and restrictive (RCM) subtypes by genetic mutation.
Available Models
Myh6 R404Q
Mybpc3 -/-
RBM20 R636Q
Thrombosis and Ischemia
Thrombosis and ischemia models replicate clot formation across arterial and venous compartments, enabling evaluation of antithrombotic agents and ischemic tissue injury.
Avilable Models
FeCl3-induced Carotid Artery Thrombosis
Photochemical Reaction MCAO
IVC Stenosis

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Our most widely used metabolic disease models with proven track records in preclinical research.

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Cardiovascular Diseases

Disease Categories

Heart Failure

Heart Failure with Reduced Ejection Fraction (HFrEF)

Heart Failure with Preserved Ejection Fraction (HFpEF)

Coronary Heart Disease (CHD)

Cardiorenal Syndrome

Cardiomyopathy (CMP)

Thrombosis and Ischemia

Featured Models

Platform Capabilities

Echocardiography (ECHO)

Pressure-Volume Loop (PV loop)

Electrocardiogram (ECG)

Treadmill