Pain Rat Models

Pain is a common symptom across a wide range of diseases and can substantially impair quality of life. The mechanisms underlying pain vary across different diseases, which in turn determines the need for different pharmacological treatments. We have an exceptionally well-developed rat experimental platform that provides a wide variety of rat models for the research and development of drugs targeting new therapeutic targets—ranging from neuropathic pain to inflammatory pain—offering numerous options for pharmacodynamic studies.

See Models

15+
Pain Rat Models
10+
Behavioral Instruments
50+
Studies Completed

Advantages

GemPharmatech's Rat Pain Research Platform

Supporting Preclinical Evaluation of Analgesic Candidates

Various Clinically Relevant Models

Covers a wide range of rat models related to clinical pain. These models can reproduce core phenotypes such as mechanical and thermal hypralgesia, spontaneous pain, paw edema, and facial allodynia, and are suitable for preclinical research ranging from new target validation to the evaluation of analgesic efficacy.

Standardized Behavioral Processes

Establish a standardized, multi-parameter behavioral assessment protocol. By standardizing baseline conditions, the observation window, and post-dosing assessment time points, this protocol facilitates a systematic comparison of acute and long-term dosing regimens.

Stable Induction and Surgical Procedures

Using standardized induction and surgical procedures, the model exhibits a stable and reproducible phenotype, supported by pathological validation; facilitating the planning of pharmacodynamic windows and mechanism-of-action studies.

Model Library

GemPharmatech's Rat Pain Disease Models Portfolio

Comprehensive rat pain models for preclinical research

Pain Rat Models

Inquiry

Disease Subtype

Models

Type

Custom Link

anchor

Models

Type

Acute-Inflammatory Pain

Formalin-Induced Pain Rat Model

Chronic-Inflammatory Pain

CFA-Induced Pain Rat Model

Neuropathic Pain

Chronic Constriction Injury (CCI) Rat Model

Infraorbital Nerve Chronic Constriction Injury (ION-CCI) Rat Model

Type 1 Diabetic Peripheral Neuropathic Pain (DPNP)

Type 2 Diabetic Peripheral Neuropathic Pain (DPNP)

Paclitaxel-Induced Pain Rat Model

Migraine-Related Pain

Nitroglycerin (NTG)-Induced Acute/Chronic Migraine Model

Mixed Pain

Endometriosis (EMT) Rat Model

Nociceptive Pain

Plantar Incision Rat Model

Cancer Pain

Walker256 Induced Bone Cancer Pain

Arthritic Pain

Collagen-Induced Arthritis

MIA-Induced Osteoarthritis (OA) Rat Model

ACLT (Anterior Cruciate Ligament Transection) + DMM (Partial Meniscectomy) OA

OVX (ovariectomy) + ACLT + DMM Induced OA

Case Studies

Case Studies & Validation Data

Explore our validated pain studies demonstrating the efficacy of various therapeutic interventions.

Formalin Pain

Naproxen Reduces Pain Response in Formalin-Induced Inflammatory Pain Model

Learn more

Naproxen Reduces Pain Response in Formalin-Induced Inflammatory Pain Model

Panel A & B: After formalin injection, mice show increased licking of the injected paw and elevated lifting of the leg. The anti-inflammatory drug Naproxen can reduce the pain response in the second phase of formalin-induced pain mouse model.