The World's Largest KO/cKO Mouse Resource Bank, With Off-The-Shelf Availability

Standard turnaround is 3 to 6 months. The exact timeline depends on factors like gene size, strategy design, and whether preliminary resources (such as embryonic stem cells or CRISPR-ready constructs) already exist. For some high-priority genes, existing cryopreserved strains can be recovered faster. Projects involving complex edits (like multiple floxed sites or tissue-specific promoters) may take longer, but our team provides detailed project timelines up front.

You can begin by searching our strain catalog or contacting us directly with your gene of interest. Use the inquiry form at the bottom of this page to provide details such as strain number, background, and desired format (live, cryopreserved, or sperm). Our scientific and sales teams will confirm availability, delivery timelines, and any additional options for  customization. For genes not yet available, we’ll walk you through the custom model generation process.

Yes. GemPharmatech offers a full service platform designed to support researchers from early discovery through preclinical testing. This includes: • Phenotyping to characterize the effects of gene knockouts • Drug efficacy testing in KO and cKO models • In vitro assays and pathology analysis • Custom breeding and colony management • Microbiome and germ-free services when needed This integration reduces the need to coordinate multiple vendors and keeps your research moving efficiently.

KO and cKO models are widely used across many fields of biomedical research. Examples include: • Oncology: tumor suppressor gene knockouts to model cancer initiation and drug resistance • Immunology & Autoimmunity: cKO models that reveal immune cell-specific gene functions • Metabolic Disease: studying genes linked to obesity, diabetes, and lipid metabolism • Neuroscience: KO models that mimic Alzheimer’s, Parkinson’s, or ALS • Cardiovascular Research: models of atherosclerosis, hypertension, and cardiomyopathy • Drug Discovery & Target Validation: confirming whether disabling a gene is therapeutic before advancing to clinical trials

Most strains are available as live mice, cryopreserved embryos, or sperm. Cryopreserved options allow for cost-efficient storage and later recovery. For active projects, live deliveries in specific ages or sexes can be arranged. Our team will confirm the options available for your chosen strain during the ordering process.