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Oncology

Preclinical Models of Cancer Cachexia: Bridging the Gap to Clinical Applications

2025-05-01

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Cancer cachexia (CC) is a multifaceted syndrome affecting up to 80% of advanced cancer patients. Characterized by unintentional weight loss, skeletal muscle wasting, and fat depletion, CC significantly impairs quality of life, treatment tolerance, and survival. Effective therapeutic options remain limited, underscoring the urgent need for preclinical models that closely mimic clinical symptoms to support drug development.


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