Inflammatory Bowel Disease Models

Wild Mouse 750
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Inflammatory bowel disease (IBD) is a chronic nonspecific inflammatory disease. It mainly includes Crohn disease (CD) and ulcerative colitis (UC).

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1. DSS-induced UC model



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Validation data

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Cyclosporine A (CsA) alleviated weight loss and decreased disease activity index (DAI) score in UC mice. And the pathological symptoms such as epithelial exfoliation of colon mucosa and inflammatory cell infiltration were relieved.

 

2. DNBS-induced colitis model 




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Validation data


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 Compared with G1 group, DAI score in model group was significantly higher.

 

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After treatment with 5-aminosalicylic acid in G2 group, HE pathological score decreased significantly, and pathological symptoms such as necrosis, exfoliation and inflammatory cell infiltration of colonic mucosa were relieved

 

3. IL-10 KO colitis model

 

Model features of B6-IL-10 KO mice

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  • Chronic IBD model that is capable of characterising more accurate histological phenotypes than actue IBD models;

  • Spontaneously aqucire colitis-related colonic inflammation after 6 months;

  • Extented and abundant window period for drug administration. More suitable for the investigation of probiotics and prebiotics;

 

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No obvious pathological changes were observed in jejunum and ileum; Degeneration/necrosis/deletion of the mucosal epithelium and intestinal glands were observed in colon; Inflammatory cell infiltration and fibrous tissue hyperplasia in Lamina propria, submucosa, muscularis, adventitia; Few muscular cyst was observed; The incidence and severity of male were slightly higher than those in females.