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Protein O-GlcNAcylation: A Sweet “Weep & Sweep” for Helminth Expulsion

O-GlcNAcylation is a post-translational modification controlled by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). In a trophic and stress-responsive manner, these two enzymes regulate the dynamic O-GlcNAcylation cycle on a diverse group of membrane-bound, nuclear, and mitochondrial proteins. The metabolic sensor O-GlcNAc, capable of receiving and integrating signals from multiple signaling pathways, targets a variety of substrates with spatiotemporal precision for subcellular translocation. In this webinar, Professor Ruan will discuss his research on the role of O-GlcNAc in various biological systems, focusing on the interactions between metabolism and immunity.


  • Role of O-GlcNAc in the interplay between intestinal epithelium and gut microbiome.

  • O-GlcNAc’s role in type 2 immune response and immune function of regulatory T cells (Treg).


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Selecting the Right Humanized Mouse Model for Immuno-Oncology Programs: A Practical Guide to Improving Translational Success

Selecting the right humanized mouse model is one of the most consequential decisions in immuno-oncology (IO) drug development. The wrong model can mask safety liabilities, inflate efficacy estimates, and weaken the data supporting regulatory submissions. Join GemPharmatech for a data-driven webinar on how strategic humanized mouse model selection strengthens preclinical decision-making, sharpens translational relevance, and supports IND-enabling studies.

meetingDate2026-07-30 00:00:00

meetingDuration11:00 AM ET

moderatorXinjie Lian

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Applications of Genetically Engineered Mouse Models for Hypertrophic Cardiomyopathy Research

Hypertrophic cardiomyopathy (HCM) is a prevalent and genetically heterogeneous cardiovascular disorder, with approximately 55% of familial cases linked to mutations in sarcomeric genes. To enable mechanistic and therapeutic studies, GemPharmatech has successfully developed two HCM mouse models: the Mybpc3 knockout (KO) and the Myh6 R404Q (point mutation) strains.

meetingDate2026-06-25 00:00:00

meetingDuration11:00 AM ET

moderatorYue Shen, Ph.D.

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Overcoming ADC Resistance: Construction and Preclinical Applications of Enhertu-Resistant Models

Antibody-drug conjugates (ADCs), particularly the HER2-targeting Enhertu (DS-8201), have revolutionized targeted cancer therapy. Despite their clinical success, drug resistance remains a major hurdle limiting long-term therapeutic benefits. To address this challenge, GemPharmatech has developed multiple ADC resistance models, including a HER2-positive JIMT-1 breast cancer xenograft (CDX) model with acquired resistance to Enhertu, and a primary Enhertu-resistant HER2-positive lung cancer model from our patient-derived xenograft (PDX) library. Join us to explore how these Enhertu-resistant models serve as translational tools to elucidate resistance mechanisms and evaluate novel therapeutic strategies.

meetingDate2026-04-14 00:00:00

meetingDuration11:00 AM ET

moderatorShiying Guo, Ph.D.

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