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Oncology

KPC Mouse Model and Cell Line for Pancreatic Cancer Therapy Research

Pancreatic ductal adenocarcinoma is a highly malignant pancreatic cancer, accounting for more than 90% of malignant pancreatic tumors. To understand the progression of pancreatic cancer and improve oncology drug development, GemPharmatech developed a spontaneous KPC tumor mouse model by introducing Kras G12Dand P53 R172H point mutations in B6 mice. This spontaneous KPC tumor model and the primary tumor luciferase cell line (mPAKPC) developed from the KPC mouse model are powerful tools for pancreatic cancer research and evaluating cancer drug efficacy. In addition to the KPC mouse and cell-line models, we also provide various spontaneous tumor model resources for preclinical drug development.


Keypoints that will be discussed in this webinar：

  • An introduction to pancreatic cancer

  • Establishment of mPAKPC tumor model and luciferase cell line

  • Application of mPAKPC tumor model for the evaluation of oncology therapeutics

  • Spontaneous tumor model resources


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Selecting the Right Humanized Mouse Model for Immuno-Oncology Programs: A Practical Guide to Improving Translational Success

Selecting the right humanized mouse model is one of the most consequential decisions in immuno-oncology (IO) drug development. The wrong model can mask safety liabilities, inflate efficacy estimates, and weaken the data supporting regulatory submissions. Join GemPharmatech for a data-driven webinar on how strategic humanized mouse model selection strengthens preclinical decision-making, sharpens translational relevance, and supports IND-enabling studies.

meetingDate2026-07-30 00:00:00

meetingDuration11:00 AM ET

moderatorXinjie Lian

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On-Demand

Applications of Genetically Engineered Mouse Models for Hypertrophic Cardiomyopathy Research

Hypertrophic cardiomyopathy (HCM) is a prevalent and genetically heterogeneous cardiovascular disorder, with approximately 55% of familial cases linked to mutations in sarcomeric genes. To enable mechanistic and therapeutic studies, GemPharmatech has successfully developed two HCM mouse models: the Mybpc3 knockout (KO) and the Myh6 R404Q (point mutation) strains.

meetingDate2026-06-25 00:00:00

meetingDuration11:00 AM ET

moderatorYue Shen, Ph.D.

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Overcoming ADC Resistance: Construction and Preclinical Applications of Enhertu-Resistant Models

Antibody-drug conjugates (ADCs), particularly the HER2-targeting Enhertu (DS-8201), have revolutionized targeted cancer therapy. Despite their clinical success, drug resistance remains a major hurdle limiting long-term therapeutic benefits. To address this challenge, GemPharmatech has developed multiple ADC resistance models, including a HER2-positive JIMT-1 breast cancer xenograft (CDX) model with acquired resistance to Enhertu, and a primary Enhertu-resistant HER2-positive lung cancer model from our patient-derived xenograft (PDX) library. Join us to explore how these Enhertu-resistant models serve as translational tools to elucidate resistance mechanisms and evaluate novel therapeutic strategies.

meetingDate2026-04-14 00:00:00

meetingDuration11:00 AM ET

moderatorShiying Guo, Ph.D.

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