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Oncology

NCG-MHC-dKO mouse-lacks GvHD, an ideal model for PBMC reconstitution and pharmacodynamic evaluation

2023-04-21

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Deleting the MHC I (H2K1, H2D1) and MHC Il (H2Ab1) genes created an in vivo environment that prolonged survival and reduced GvHD occurrence upon human PBMC engraftment. This ultimately allows for a more extended study observation window. In this model, the half-life of IgG is maintained, unlike that in NCG-β2m
KO, which will give a better pharmacodynamic and pharmacokinetic study. In conclusion, the NCG-MHC-dKO is a suitable model for preclinical lgG antibody evaluation and PBMC reconstitution.


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