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Oncology

Analysis of selective response of anti-PD-L1 treatment in huPBMC-NCG mice reconstituted with different donors

2023-04-21

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MDA-MB-231 and NUGC4 PBMC-NCG xenograft models were included in this study. In the case of MDA-231, 3 donors were enrolled in this study at the same time. The TGITV of 3 donors were 17.66-MB%, 27.14%, and 52.40%, especially. In the case of NUGC4, 2 donors were enrolled in this study at the same time. The TGITV of 2 donors were 4.75% and 20.74%, especially. The results of two experiments suggested that the anti-PDL1 treatment are donor dependent, which is similar to the clinical trials.


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