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Oncology

Humanized FcRn Mouse Model: A Superior Platform for Predicting Human PK of Therapeutic Antibodies

2026-04-23

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Accurate prediction of pharmacokinetics (PK) is critical for monoclonal antibody development, yet conventional mouse models often fail to recapitulate human IgG half-life due to species differences in FcRn binding. GemPharmatech has developed a humanized FcRn mouse model expressing the human FcRn transgene on a murine FcRn-deficient background. In vivo PK studies with human IgG1 and pembrolizumab (Keytruda) demonstrated significantly improved correlation with clinical human data, including more accurate serum half-life compared to wild-type mice. This humanized FcRn model offers a robust and translational platform for preclinical PK evaluation and optimization of therapeutic antibodies.


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