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Oncology

B6-Kras<sup>LSL-G12C</sup> mouse model for assessing the occurrence and development of spontaneous tumors in the lung

2023-04-21

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We constructed the KrasLSL-G12C mouse model that caries the G12C point mutation in the Kras gene with a loxP-flanked Stop cassette, enabling Cre-dependent KrasG12C expression in target organs. Kras mRNA with G12C mutation was successfully detected when the KrasLSL-G12C mice were crossed with tissue-specific Cre mice.

Two spontaneous tumor models of lung cancer with distinct features of tumorigenesis and progression were developed by crossing KrasLSL-G12C mice with Sftpc-IRES-iCre and Lyz2-iCre, respectively.

The KrasLSL-G12C; LyZ2-iCre model is a novel model to study metastatic lung cancers into the liver and possibly other organs.


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