Gout/Hyperuricemia Models
Hyperuricemia (HUA) is a common purine metabolic disorder caused by excessive synthesis or decreased excretion of uric acid. Gout is precipitated by hyperuricemia, which is also linked to cardiovascular diseases and chronic renal failure. Many factors, including genetics, gender, age, lifestyle, and diet, contribute to the development of hyperuricemia. As research on HUA has progressed, developing adequate animal models of hyperuricemia has become a pressing issue for elucidating its pathophysiology and developing therapeutic medicines.
GemPharmatech constructed the UOX-KO mouse model by knocking out exons 2-4 of the murine Uox gene on a C57BL/6JGpt background. The abnormal accumulation of uric acid following the loss of UOX expression leads to the development of hyperuricemia in mice, making this an ideal model for the screening and efficacy evaluation of drugs for the treatment of hyperuricemia.
|
Strain No.
|
Strain Name | Strain Type | Description |
|---|---|---|---|
| T011801 | Uox-KO | KO | This spontaneous hyperuricemia model exhibits significantly high uric acid concentration and can be used to study hyperuricemia, uric acid nephropathy, and the efficacy of related therapeutic medications. |
| T054549 | B6-hXDH | KI | The CDS and 3’UTR regions of the human XDH gene were introduced into C57BL/6JGpt mice, successfully creating a humanized XDH mouse model. This model can be used for the efficacy evaluation of human hyperuricemia-related drugs, such as XDH inhibitors or small nucleic acid drugs. |