BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Trp53em1Cd2494/Gpt |
| Strain Number: | T005332 |
| Official Symbol: | Trp53 |
| Strain Strategy: | T005332.B6-p53 KO strain info.pdf |
| Official Full Name: | transformation related protein 53 |
| Also Known As: | Tp53,bbl,bfy,bhy,p44,p53 |
| NCBI Number: | 22059 |
| MGI Number: | 98834 |
| Chromosome: | 11 |
| Research Areas: | Disease Models,Tumor model,Spontaneous tumor |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Inventory Status: | Live,Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival. Cell Rep (2022)2. p53 promotes peroxisomal fatty acid beta-oxidation to repress purine biosynthesis and mediate tumor suppression. Cell Death & Disease (2023)3. Pharmacological rescue of mutant p53 triggers spontaneous tumor regression via immune responses. Cell reports. Medicine (2025) |