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Metabolism

Mouse Models with a Chromosome Derived from Wild Mice

Inbred mice have been extensively used in scientific research and the pharmaceutical industry. The clear and consistent genetic background of inbred mice offers advantages in experimental consistency and repeatability while presenting limitations in genetic diversity. The lack of genetic diversity is thought to be an important reason for the poor translatability between preclinical and clinical trial results. The natural population of wild mice is rich in genetic diversity, including variations such as single nucleotide polymorphisms (SNP), sequence deletions and duplications. Introducing chromosomes of wild mice into inbred mice provides new experimental animal resources for the study of complex traits.


Topics for this webinar include:

  • Discussion about the advantages and limitations of inbred mice.

  • An introduction to our Wild Mouse Project.

  • Phenotypes of a mouse model with a chromosome 1 substitution derived from wild mice

  • Applications for using this mouse model for studying new drug targets .


1st Broadcast: KST 20:00, CEST 13:00, December 20th, 2022

2nd Broadcast: EDT 15:00, PDT 12:00, December 20th, 2022


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Upcoming

Selecting the Right Humanized Mouse Model for Immuno-Oncology Programs: A Practical Guide to Improving Translational Success

Selecting the right humanized mouse model is one of the most consequential decisions in immuno-oncology (IO) drug development. The wrong model can mask safety liabilities, inflate efficacy estimates, and weaken the data supporting regulatory submissions. Join GemPharmatech for a data-driven webinar on how strategic humanized mouse model selection strengthens preclinical decision-making, sharpens translational relevance, and supports IND-enabling studies.

meetingDate2026-07-30 00:00:00

meetingDuration11:00 AM ET

moderatorXinjie Lian

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On-Demand

Applications of Genetically Engineered Mouse Models for Hypertrophic Cardiomyopathy Research

Hypertrophic cardiomyopathy (HCM) is a prevalent and genetically heterogeneous cardiovascular disorder, with approximately 55% of familial cases linked to mutations in sarcomeric genes. To enable mechanistic and therapeutic studies, GemPharmatech has successfully developed two HCM mouse models: the Mybpc3 knockout (KO) and the Myh6 R404Q (point mutation) strains.

meetingDate2026-06-25 00:00:00

meetingDuration11:00 AM ET

moderatorYue Shen, Ph.D.

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Overcoming ADC Resistance: Construction and Preclinical Applications of Enhertu-Resistant Models

Antibody-drug conjugates (ADCs), particularly the HER2-targeting Enhertu (DS-8201), have revolutionized targeted cancer therapy. Despite their clinical success, drug resistance remains a major hurdle limiting long-term therapeutic benefits. To address this challenge, GemPharmatech has developed multiple ADC resistance models, including a HER2-positive JIMT-1 breast cancer xenograft (CDX) model with acquired resistance to Enhertu, and a primary Enhertu-resistant HER2-positive lung cancer model from our patient-derived xenograft (PDX) library. Join us to explore how these Enhertu-resistant models serve as translational tools to elucidate resistance mechanisms and evaluate novel therapeutic strategies.

meetingDate2026-04-14 00:00:00

meetingDuration11:00 AM ET

moderatorShiying Guo, Ph.D.

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