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Oncology

Immunodeficient Mouse Models for Cancer and Immunotherapy Research: NCG and Next-Generation NCG Mice

Speaker: Santi Suryani Chen, PhD


The development of immunodeficient mouse models has advanced our understanding of how cancer progresses and has drastically improved oncology and immuno-oncology drug development research. GemPharmatech has carefully developed the NCG mouse strain, which lacks T, B, and NK cells, making it one of the most comprehensive immunodeficient mouse models available. Our NCG mice are powerful tools for modeling human diseases and are widely used for cancer immunotherapy research using cell derived xenografts (CDX) and patient derived xenografts (PDX). These mice are also ideal for immune system reconstitution using human peripheral blood mononuclear cells (PBMC) or human hematopoietic stem cells (HSC). Topics for this webinar include:

  • An introduction to our NCG mice

  • Discussion about the advantages, benefits, and limitations of our NCG mouse models

  • Overview of our Next-Generation NCG strains and their role in oncology research

  • Applications for using humanized and immune reconstituted NCG mice for evaluation of oncology drug development


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Selecting the Right Humanized Mouse Model for Immuno-Oncology Programs: A Practical Guide to Improving Translational Success

Selecting the right humanized mouse model is one of the most consequential decisions in immuno-oncology (IO) drug development. The wrong model can mask safety liabilities, inflate efficacy estimates, and weaken the data supporting regulatory submissions. Join GemPharmatech for a data-driven webinar on how strategic humanized mouse model selection strengthens preclinical decision-making, sharpens translational relevance, and supports IND-enabling studies.

meetingDate2026-07-30 00:00:00

meetingDuration11:00 AM ET

moderatorXinjie Lian

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Applications of Genetically Engineered Mouse Models for Hypertrophic Cardiomyopathy Research

Hypertrophic cardiomyopathy (HCM) is a prevalent and genetically heterogeneous cardiovascular disorder, with approximately 55% of familial cases linked to mutations in sarcomeric genes. To enable mechanistic and therapeutic studies, GemPharmatech has successfully developed two HCM mouse models: the Mybpc3 knockout (KO) and the Myh6 R404Q (point mutation) strains.

meetingDate2026-06-25 00:00:00

meetingDuration11:00 AM ET

moderatorYue Shen, Ph.D.

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Overcoming ADC Resistance: Construction and Preclinical Applications of Enhertu-Resistant Models

Antibody-drug conjugates (ADCs), particularly the HER2-targeting Enhertu (DS-8201), have revolutionized targeted cancer therapy. Despite their clinical success, drug resistance remains a major hurdle limiting long-term therapeutic benefits. To address this challenge, GemPharmatech has developed multiple ADC resistance models, including a HER2-positive JIMT-1 breast cancer xenograft (CDX) model with acquired resistance to Enhertu, and a primary Enhertu-resistant HER2-positive lung cancer model from our patient-derived xenograft (PDX) library. Join us to explore how these Enhertu-resistant models serve as translational tools to elucidate resistance mechanisms and evaluate novel therapeutic strategies.

meetingDate2026-04-14 00:00:00

meetingDuration11:00 AM ET

moderatorShiying Guo, Ph.D.

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