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Oncology

Human Immune Reconstituted Mice in Translational Medicine: Challenges and Solutions

11:00 AM ET

60 min

Huiyi Wang, Ph.D.

Over the past few years, GemPharmatech has developed several new strains of transgenic immunodeficient mice on our proprietary NCG background. These next-generation NCG strains have additional benefits such as supporting higher levels of human immune system reconstitution or slowing the occurrence of GVHD. These models are of great significance for basic research in immunology, evaluating preclinical efficacy, and understanding the function of the human immune system in vivo. They are also increasingly being used as efficacy and safety models to evaluate new therapies and approaches in immuno-oncology, autoimmune diseases, and infection-related drugs prior to their application in humans.

The topics for this webinar will include:

  • An introduction to our NCG and NCG derivatives

  • An overview of our next-generation NCG strains and their role in immuno-oncology and autoimmune research


PDT 8:00 am | CDT 10:00 am | EDT 11:00 am | CEST 17:00 pm, April 4th, 2023

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Selecting the Right Humanized Mouse Model for Immuno-Oncology Programs: A Practical Guide to Improving Translational Success

Selecting the right humanized mouse model is one of the most consequential decisions in immuno-oncology (IO) drug development. The wrong model can mask safety liabilities, inflate efficacy estimates, and weaken the data supporting regulatory submissions. Join GemPharmatech for a data-driven webinar on how strategic humanized mouse model selection strengthens preclinical decision-making, sharpens translational relevance, and supports IND-enabling studies.

meetingDate2026-07-30 00:00:00

meetingDuration11:00 AM ET

moderatorXinjie Lian

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Applications of Genetically Engineered Mouse Models for Hypertrophic Cardiomyopathy Research

Hypertrophic cardiomyopathy (HCM) is a prevalent and genetically heterogeneous cardiovascular disorder, with approximately 55% of familial cases linked to mutations in sarcomeric genes. To enable mechanistic and therapeutic studies, GemPharmatech has successfully developed two HCM mouse models: the Mybpc3 knockout (KO) and the Myh6 R404Q (point mutation) strains.

meetingDate2026-06-25 00:00:00

meetingDuration11:00 AM ET

moderatorYue Shen, Ph.D.

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Overcoming ADC Resistance: Construction and Preclinical Applications of Enhertu-Resistant Models

Antibody-drug conjugates (ADCs), particularly the HER2-targeting Enhertu (DS-8201), have revolutionized targeted cancer therapy. Despite their clinical success, drug resistance remains a major hurdle limiting long-term therapeutic benefits. To address this challenge, GemPharmatech has developed multiple ADC resistance models, including a HER2-positive JIMT-1 breast cancer xenograft (CDX) model with acquired resistance to Enhertu, and a primary Enhertu-resistant HER2-positive lung cancer model from our patient-derived xenograft (PDX) library. Join us to explore how these Enhertu-resistant models serve as translational tools to elucidate resistance mechanisms and evaluate novel therapeutic strategies.

meetingDate2026-04-14 00:00:00

meetingDuration11:00 AM ET

moderatorShiying Guo, Ph.D.

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