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Oncology

Preclinical PD-1 Resistance Models: Crucial Tools for Unveiling PD-1 Resistance Mechanisms and Advancing Novel Treatment Strategies

2024-04-10

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The interaction between PD-1 and PD-L1 promotes tumor immune evasion, but immune checkpoint inhibitors can reinvigorate the immune system. However, most patients don't respond well to anti-PD-1/PD-L1 therapy, leading to acquired resistance. Establishing reliable preclinical resistance models is vital for understanding resistance mechanisms and developing new treatments.


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