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Oncology

Patient-derived xenograft (PDX) models with differential HER2 expression for preclinical evaluation of HER2-targeted therapies

2024-04-10

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HER2 overexpression is common in gastric and gastroesophageal cancer, emphasizing the need to target HER2 in treatment. Gempharmatech offers PDX gastric cancer models with varying HER2 levels, identified through immunohistochemistry. These models, exemplified by one with heterogeneous HER2 expression, provide detailed insights into drug responses, particularly highlighting the efficacy of Trastuzumab deruxtecan, contributing to precision medicine in HER2-targeted therapy development.


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