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Oncology

NCG-X: A Novel Mouse Model For Preclinical Studies Evaluating Humanized Erythroid Reconstitution

2025-06-18

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Hematopoietic stem cell (HSC) transplantation is critical for treating blood cancers and autoimmune diseases, but existing animal models rely on toxic preconditioning (irradiation/chemotherapy), leading to off-target effects that undermine research validity. To overcome this, we developed the NCG-X mouse by introducing a C-KIT (Val831Met) mutation into the NCG mouse. This model enables human HSC engraftment without irradiation or chemoablation, offering a promising platform for immune and erythroid reconstitution studies.


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