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Oncology

Mouse Models of anti-PD-1 Resistance Reveals Insights into Resistance Mechanisms

2025-05-01

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Although cancer immunotherapy utilizing blockade of the PD-1/PD-L1 checkpoint has revolutionized the treatment of a wide variety of malignancies, leading to durable therapeutic responses, it is ineffective in many patients who developed drug resistance after initial response. Therefore, the establishment of robust preclinical anti-PD-1 resistance models is of paramount importance for unraveling drug resistance mechanisms and developing novel treatment strategies.


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