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Oncology

Development of a Novel Murine Model, NCG-M/hIL15, for Enhanced Post-HSC Transplantation Immunoreconstruction

2024-11-20

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Advances in immunology and hematopoietic stem cell (HSC) transplantation have led to the development of murine models that faithfully recapitulate human immune responses. GemPharmatech has developed the NCG-M/hIL15 model, which expresses human granulocyte-macrophage colony-stimulating factor 2 (GM-CSF), interleukin-3 (IL-3), stem cell factor (SCF), and interleukin-15 (IL-15) in the severely immunodeficient NCG mouse. The goal of developing this model is to support a broader reconstitution of the human immune system, including T cells, myeloid cells, and NK cells, following HSC engraftment.


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