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Oncology

BALB/c-hIL12RB1/hIL12RB2: A Robust Model for Preclinical Research in Human IL-12 Therapy

2024-04-10

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Recent interest in Interleukin-12 (IL-12) as a therapeutic target led to the development of the BALB/c-hIL12RB1/hIL12RB2 humanized mouse model, preserving intracellular signaling and effectively expressing human IL12RB1 and IL12RB2. This model demonstrates enhanced activation of cytotoxic lymphocytes, natural killer cells, and interferon production, validating IL-12 as a potential anti-tumor drug target. Successful validation of the model suggests its utility in understanding IL-12's therapeutic mechanisms and developing novel anti-tumor treatments.


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