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Oncology

Allograft and xenograft GvHD mouse models for efficacy evaluation of Anti-GvHD drugs and research in immunoregulation

2023-04-21

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Both allogenic and xenogenic GvHD models were able to simulate clinical GvHD symptoms. Both models responded to known anti-GvHD drugs effectively and showed evident improvement of GvHD after treatment.

Taken together, the two GvHD models we have developed show great potential for preclinical evaluation of anti-GvHD drugs. They can be used for studying the pathophysiology of GvHD.


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