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Metabolism

A Persistent Hypertension Model Developed on the AGT Humanized Mice

2025-06-23

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Hypertension, a major metabolic syndrome condition, has experienced a rapid increase in global prevalence. AGT (angiotensinogen), the key precursor in the RAAS pathway, serves as a prime target for RNAi therapies. GemPharmatech has developed an AGT humanized mouse model to advance hypertension research and developed a modified human RENIN virus to induce sustained high blood pressure in these mice—a critical step for preclinical evaluation.


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