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BKS-Leprem2Cd479/Gpt

BKS-db|Strain NO.T002407

Knockout (KO)

BASIC INFORMATION
Strain Name: BKS-Leprem2Cd479/Gpt
Strain Number: T002407
Official Symbol: Lepr,db
Strain Strategy: T002407.BKS-db strain info.pdf
Official Full Name: leptin receptor
Also Known As: LEPROT,Leprb,Modb1,OB-RGRP,Obr,db,diabetes,obese-like,obl
NCBI Number: 16847
MGI Number: 104993
Chromosome: 4
Research Areas: Disease Models,Metabolic Disease,Diabetes model,Obesity model
Strain Background: [N000214] C57BLKS/JGpt
Modification Type: Knockout (KO)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice. Nat Commun (2023)2. Aqueous extract of Scrophularia ningpoensis improves insulin sensitivity through AMPK-mediated inhibition of the NLRP3 inflammasome. Phytomedicine (2022)3. Celastrol inhibits TXNIP expression to protect pancreatic β cells in diabetic mice. Phytomedicine (2022)4. Inulin-Type Fructans Change the Gut Microbiota and Prevent the Development of Diabetic Nephropathy. Pharmacological Research (2022)5. Hepatic leptin signaling improves hyperglycemia by stimulating MAPK phosphatase-3 protein degradation via STAT3. Cellular and Molecular Gastroenterology and Hepatology (2022)6. A novel mouse model of diabetes, atherosclerosis and fatty liver disease using an AAV8-PCSK9-D377Y injection and dietary manipulation in db/db mice. Biochemical and Biophysical Research Communications (2022)7. m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin. Autophagy (2022)8. Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation. Acta Pharmaceutica Sinica B (2021)9. Elevated branched-chain α-keto acids exacerbate macrophage oxidative stress and chronic inflammatory damage in type 2 diabetes mellitus. Free Radical Biology and Medicine (2021)10. VDR/Atg3 axis regulates slit diaphragm to tight junction transition via p62-mediated autophagy pathway in diabetic nephropathy. Diabetes (2021)11. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism. Cell metabolism (2021)12. Peroxiredomin-4 ameliorates lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy. Biomedicine & Pharmacotherapy (2021)13. MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice. Metabolism (2021)14. Human foreskin-derived dermal stem/progenitor cell-conditioned medium combined with hyaluronic acid promotes extracellular matrix regeneration in diabetic wounds. Stem cell research & therapy (2021)15. High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy. Cell death & disease (2021)16. Cdk5-mediated phosphorylation of Sirt1 contributes to podocyte mitochondrial dysfunction in diabetic nephropathy. Antioxidants & Redox Signaling (2021)17. Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. Analytical Chemistry (2021)18. circRNA_010383 acts as a sponge for miR-135a, and its downregulated expression contributes to renal fibrosis in diabetic nephropathy. Diabetes (2021)19. A novel GLP-1 and FGF21 dual agonist has therapeutic potential for diabetes and non-alcoholic steatohepatitis. EBioMedicine (2021)20. CCR2-engineered mesenchymal stromal cells accelerate diabetic wound healing by restoring immunological homeostasis. Biomaterials (2021)21. RIPK3-Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation. Oxidative Medicine and Cellular Longevity (2021)22. Purβ promotes hepatic glucose production by increasing Adcy6 transcription. Molecular metabolism (2020)23. Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo. Advanced Science (2020)24. SIK2 protects against renal tubular injury and the progression of diabetic kidney disease. Transl Res (2022)25. A composite hydrogel containing resveratrol-laden nanoparticles and platelet-derived extracellular vesicles promotes wound healing in diabetic mice. Acta Biomaterialia (2022)26. Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88-Dependent Inflammation. Adv Sci (Weinh) (2022)27. Pancreatic alpha cell glucagon-liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes. Diabetologia (2022)28. ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation. Redox Biol (2022)29. Positive feedback loop of miR-320 and CD36 regulates the hyperglycemic memory-induced diabetic diastolic cardiac dysfunction. Mol Ther Nucleic Acids (2023)30. THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic beta-cell function and preserving beta-cell mass. Nature Communications (2023)31. Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing. Cell Rep Med (2023)32. A novel mouse model of heart failure with preserved ejection fraction after chronic kidney disease induced by retinol through JAK/STAT pathway. Int J Biol Sci (2023)33. Balancing adipocyte production and lipid metabolism to treat obesity-induced diabetes with a novel proteoglycan from Ganoderma lucidum. Lipids Health Dis (2023)34. Proteoglycan Extracted from Ganoderma lucidum Ameliorated Diabetes-Induced Muscle Atrophy via the AMPK/SIRT1 Pathway In Vivo and In Vitro. ACS Omega (2023)35. mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1. Nature metabolism (2022)36. Identification and validation of voltage-dependent anion channel 1-related genes and immune cell infiltration in diabetic nephropathy. J Diabetes Investig (2023)37. Sodium tanshinone IIA sulfonate ameliorates neointima by protecting endothelial progenitor cells in diabetic mice. BMC Cardiovasc Disord (2023)38. Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice. Biocell (2023)39. Diabetes mellitus promotes the nasal colonization of high virulent Staphylococcus aureus through the regulation of SaeRS two-component systemnasal colonized S. aureus in type 2 diabetes. Emerg Microbes Infect (2023)40. Inhibition of MD2 by natural product-drived JM-9 attenuates renal inflammation and diabetic nephropathy in mice. Biomed Pharmacother (2023)41. Lentinan alleviates diabetic cardiomyopathy by suppressing CAV1/SDHA-regulated mitochondrial dysfunction. Biomed Pharmacother (2023)42. Trigonelline inhibits tubular epithelial-mesenchymal transformation in diabetic kidney disease via targeting Smad7. Biomed Pharmacother (2023)43. Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease. Cell Metab (2023)44. Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1. Cell Mol Life Sci (2023)45. ApoSEVs-Mediated Modulation of Versatile Target Cells Promotes Diabetic Wound Healing: Unveiling a Promising Strategy. Int J Nanomedicine (2023)46. Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis. Acta Pharmaceutica Sinica B (2023)47. Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus. Bioactive Materials (2024)48. Ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction. Exp Mol Med (2023)49. Nephropathy Is Aggravated by Fatty Acids in Diabetic Kidney Disease through Tubular Epithelial Cell Necroptosis and Is Alleviated by an RIPK-1 Inhibitor. Kidney Dis (2023)50. Circ-0000953 deficiency exacerbates podocyte injury and autophagy disorder by targeting Mir665-3p-Atg4b in diabetic nephropathy. Autophagy (2023)51. Depletion of gut microbiota facilitates fibroblast growth factor 21-mediated protection against acute pancreatitis in diabetic mice. World Journal of Diabetes (2023)52. Fatty acid beta-oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice. J Diabetes (2023)53. Pancreatic Cancer: An Exocrine Tumor with Endocrine Characteristics. Ann Surg (2023)54. Sodium butyrate improves mitochondrial function and kidney tissue injury in diabetic kidney disease via the AMPK/PGC-1alpha pathway. Ren Fail (2023)55. Targeting YAP1-regulated Glycolysis in Fibroblast-Like Synoviocytes Impairs Macrophage Infiltration to Ameliorate Diabetic Osteoarthritis Progression. Adv Sci (2023)56. MicroRNA-204-5p Ameliorates Renal Injury via Regulating Keap1/Nrf2 Pathway in Diabetic Kidney Disease. Diabetes Metab Syndr Obes (2024)57. The Synergism of Human Lactobacillaceae and Inulin Decrease Hyperglycemia via Regulating the Composition of Gut Microbiota and Metabolic Profiles in db/db Mice. Microbial Biotechnology (2023)58. Low molecular weight fucoidan restores diabetic endothelial glycocalyx by targeting neuraminidase2: A new therapy target in glycocalyx shedding. British Journal of Pharmacology (2023)59. Early detection of cardiac fibrosis in diabetic mice by targeting myocardiopathy and matrix metalloproteinase 2. Acta Biomater (2024)60. Ultrasound Deep Brain Stimulation Regulates Food Intake and Body Weight in Mice. IEEE Transactions on Neural Systems and Rehabilitation Engineering (2024)61. Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism. Advanced Science (2023)62. Diabetes mellitus promotes the nasal colonization of high virulent Staphylococcus aureus through the regulation of SaeRS two-component system. Emerg Microbes Infect (2023)63. (Pro)renin receptor mediates tubular epithelial cell pyroptosis in diabetic kidney disease via DPP4-JNK pathway. J Transl Med (2024)64. Aged oolong tea manages type 2 diabetes mellitus by inhibiting fat ectopic deposition and alleviating insulin resistance in db/db mice. Food Frontiers (2024)65. Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor). Signal Transduct Target Ther (2024)66. Network Pharmacology, Molecular Docking, and Experimental Verification to Reveal the Mitophagy-Associated Mechanism of Tangshen Formula in the Treatment of Diabetic Nephropathy. Diabetes Metab Syndr Obes (2024)67. The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice. iScience (2024)68. Jiao-tai-wan and its effective component-berberine improve diabetes and depressive disorder through the cAMP/PKA/CREB signaling pathway. J Ethnopharmacol (2024)69. Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice. Diabetol Metab Syndr (2024)70. Compound Danshen dripping pills prevent early diabetic retinopathy: roles of vascular protection and neuroprotection. Front Pharmacol (2024)71. Trimethylamine N-oxide impairs beta-cell function and glucose tolerance. Nat Commun (2024)72. VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy. Adv Sci (2024)73. MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus. Cardiovasc Diabetol (2024)74. Assessment of Reference Genes Stability in Cortical Bone of Obese and Diabetic Mice. Diabetes Metab Syndr Obes (2024)75. PPARalpha/delta dual agonist H11 alleviates diabetic kidney injury by improving the metabolic disorders of tubular epithelial cells. Biochem Pharmacol (2024)76. Label-free analysis of the beta-hydroxybutyricacid drug on mitochondrial redox states repairment in type 2 diabetic mice by resonance raman scattering. Biomed Pharmacother (2024)77. Knockdown of ACOT4 alleviates gluconeogenesis and lipid accumulation in hepatocytes. Heliyon (2024)78. Noninvasive Monitoring of Early Cardiac Fibrosis in Diabetic Mice by [(68)Ga]Ga-DOTA-FAPI-04 PET/CT Imaging. ACS Omega (2024)79. Replenishment of mitochondrial Na(+) and H(+) by ionophores potentiates cutaneous wound healing in diabetes. Materials Today Bio (2024)80. Enhancing the Therapeutic Efficacy of GLP-1 for Hyperglycemia Treatment: Overcoming Barriers of Oral Gene Therapy with Taurocholic Acid-Conjugated Protamine Sulfate and Calcium Phosphate. ACS Nano (2024)81. Augmenter of liver regeneration knockout aggravates tubular ferroptosis and macrophage activation by regulating carnitine palmitoyltransferase-1A-induced lipid metabolism in diabetic nephropathy. Acta Physiologica (2024)82. CHILKBP protects against podocyte injury by preserving ZO-1 expression. Cell Mol Life Sci (2022)83. Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy. iScience (2024)84. Pinctada martensii Hydrolysate Modulates the Brain Neuropeptidome and Proteome in Diabetic (db/db) Mice via the Gut–Brain Axis. Marine Drugs (2024)85. Netrin-1 co-cross-linked hydrogel accelerates diabetic wound healing in situ by modulating macrophage heterogeneity and promoting angiogenesis. Bioact Mater (2024)86. The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair. Cell Metab (2024)87. Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption. Nat Metab (2024)88. Inhibition of endoplasmic reticulum stress and excessive autophagy by Jiedu Tongluo Tiaogan Formula via a CaMKKbeta/AMPK pathway contributes to protect pancreatic beta-cells. J Ethnopharmacol (2024)89. Lactate drives epithelial-mesenchymal transition in diabetic kidney disease via the H3K14la/KLF5 pathway. Redox Biol (2024)90. Plasma Asprosin Concentrations are Associated with Progression of Diabetic Kidney Disease. Diabetes Metab Syndr Obes (2024)91. Supplementation of Clostridium butyricum Alleviates Vascular Inflammation in Diabetic Mice. Diabetes Metab J (2024)92. A neural-mast cell axis regulates skin microcirculation in diabetes. Diabetes (2024)93. Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage. Nat Commun (2024)94. Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway. J Neuroinflammation (2024)95. Sodium Tanshinone IIA Sulfonate alleviates vascular senescence in diabetic mice by modulating the A20-NFkappaB-NLRP3 inflammasome-catalase pathway. Sci Rep (2024)96. Autophagy-enabled protein degradation: Key to platelet activation and ANGII production in patients with type 2 diabetes mellitus. Heliyon (2024)97. A High-Carbohydrate Diet Induces Cognitive Impairment and Promotes Amyloid Burden and Tau Phosphorylation via PI3K/Akt/GSK-3beta Pathway in db/db Mice. Biomedicines (2024)98. Human adipose‐derived multipotent stromal cells enriched with IL‐10 modRNA improve diabetic wound healing: Trigger the macrophage phenotype shift. Bioengineering & Translational Medicine (2024)99. RTP4 Enhances Corneal HSV-1 Infection in Mice With Type 2 Diabetes Mellitus. Investigative Ophthalmology & Visual Science (2024)100. Reshaped commensal wound microbiome via topical application of Calvatia gigantea extract contributes to faster diabetic wound healing. Burns & Trauma (2024)101. SGLT2 inhibitors ameliorate NAFLD in mice via downregulating PFKFB3, suppressing glycolysis and modulating macrophage polarization. Acta Pharmacologica Sinica (2024)102. Unlocking the role of wound microbiome in diabetic, burn, and germ-free wound repair treated by natural and synthetic scaffolds. Acta Pharmaceutica Sinica B (2024)103. DeSUMOylation of RBMX regulates exosomal sorting of cargo to promote renal tubulointerstitial fibrosis in diabetic kidney disease. Journal of Advanced Research (2024)104. Increase of PCSK9 expression in diabetes promotes VEGFR2 ubiquitination to inhibit endothelial function and skin wound healing. Sci China Life Sci (2024)105. Improvement of MASLD and MASH by suppression of hepatic N-acetyltransferase 10. Molecular Metabolism (2024)106. Single‐Cell RNA Sequencing Uncovers Pathological Processes and Crucial Targets for Vascular Endothelial Injury in Diabetic Hearts. Adv Sci (Weinh) (2024)107. Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression. Cell Death Dis (2024)108. Eldecalcitol ameliorates diabetic osteoporosis and glucolipid metabolic disorder by promoting Treg cell differentiation through SOCE. Cell Mol Life Sci (2024)109. Fam3a-mediated prohormone convertase switch in α-cells regulates pancreatic GLP-1 production in an Nr4a2-Foxa2-dependent manner. Metabolism (2024)110. SREBP1 induction mediates long-term statins therapy related myocardial lipid peroxidation and lipid deposition in TIIDM mice. Redox Biol (2024)111. Programmed BRD9 Degradation and Hedgehog Signaling Activation via Silk‐Based Core‐Shell Microneedles Promote Diabetic Wound Healing. Adv Sci (Weinh) (2024)112. DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1. Cell Commun Signal (2024)113. Dihydro‐resveratrol ameliorates NLRP3 inflammasome‐mediated neuroinflammation via Bnip3‐dependent mitophagy in Alzheimer's disease. Br J Pharmacol (2024)114. Nuclear Factor Erythroid 2-Related Factor 2 Activator DDO-1039 Ameliorates Podocyte Injury in Diabetic Kidney Disease via Suppressing Oxidative Stress, Inflammation, and Ferroptosis. ANTIOXIDANTS & REDOX SIGNALING (2024)115. Lactobacillus reuteri-Enriched Eicosatrienoic Acid Regulates Glucose Homeostasis by Promoting GLP-1 Secretion to Protect Intestinal Barrier Integrity. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2024)116. Berberine alleviates AGEs-induced ferroptosis by activating NRF2 in the skin of diabetic mice. Exp Biol Med (Maywood) (2024)117. Jinlida granules alleviate podocyte apoptosis and mitochondrial dysfunction via the AMPK/PGC-1α pathway in diabetic nephropathy. Int J Mol Med (2024)118. YTHDF3 suppresses declines in corneal epithelial wound healing through upregulating the Wnt/β-catenin signaling pathway and THBS2 expression in diabetic corneas. Int J Biol Macromol (2024)119. Mass Spectrometry Imaging Reveals Spatial Metabolic Alterations and Salidroside's Effects in Diabetic Encephalopathy. Metabolites (2024)120. … microbiota and intestinal FXR siganlling involved in the alleviation of mulberry (Morus alba L.) leaf ethanol extract on type 2 diabetes mellitus in db/db mice. Journal of Functional Foods (2024)121. Targeting DUSP26 to drive cardiac mitochondrial dynamics via FAK-ERK signaling in diabetic cardiomyopathy. Free Radic Biol Med (2024)122. Integrative transcriptome analysis reveals Serpine2 promotes glomerular mesangial cell proliferation and extracellular matrix accumulation via activating ERK1/2 …. Diabetes Obes Metab (2024)123. Organophosphorus Flame Retardants and Metabolic Disruption: An in Silico, in Vitro, and in Vivo Study Focusing on Adiponectin Receptors. Environ Health Perspect (2024)124. Hyperglycemia‐Enhanced Neutrophil Extracellular Traps Drive Mucosal Immunopathology at the Oral Barrier. Adv Sci (Weinh) (2024)125. Leupaxin promotes hepatic gluconeogenesis and glucose metabolism by coactivation with hepatic nuclear factor 4α. Mol Metab (2024)126. Slow Metabolism–Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone‐Induced Obesity‐Specific Liver Injury. Adv Sci (Weinh) (2024)127. Histone Lysine Crotonylation Accelerates ACSL4-Mediated Ferroptosis of Keratinocytes via Modulating Autophagy in Diabetic Wound Healing. Pharmacological research (2025)128. m6A demethylase Fto inhibited macrophage activation and glycolysis in diabetic nephropathy via m6A/Npas2/Hif‐1α axis. FASEB journal (2025)129. ZishenWan reduces obesity in db/db mice by inhibiting p21 expression in adipose tissues. Journal of Traditional and Complementary Medicine (2025)130. Free fatty acid receptor 4 modulates dietary sugar preference via the gut microbiota. Nature microbiology (2025)131. Identifying Specificity Protein 2 as a key marker for diabetic encephalopathy in the context of predictive, preventive, and personalized medicine. (2025)132. BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation. Cell communication and signaling : CCS (2025)133. Alpiniae oxyphyllae Fructus ameliorates renal lipid accumulation in diabetic kidney disease via activating PPARα. (2025)134. BDH1 overexpression alleviates diabetic cardiomyopathy through inhibiting H3K9bhb-mediated transcriptional activation of LCN2. Cardiovascular diabetology (2025)135. Antihypertensive drug amlodipine besylate shows potential in alleviating diabetic peripheral neuropathy. Diabetes (2025)136. Polyzwitterion-branched polycholic acid nanocarriers based oral delivery insulin for long-term glucose and metabolic regulation in diabetes mellitus. Journal of nanobiotechnology (2025)137. FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism. Biochemical pharmacology (2025)138. Proteomic and metabolomic profiling reveals the underlying molecular mechanisms in modified alternate-day fasting-mediated protection against Diabetic kidney disease. PloS one (2025)139. Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation. Cell reports (2025)
Gene Family: CD moleculesImmunoglobulin like domain containing