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C57BL/6JGpt-
Ldlr
em1Cd82
/Gpt
Ldlr-KO|Strain NO.T001464
Knockout (KO)
Product Type:
Live Mouse
Live Mouse
Frozen Embryo
Quantity:
-
+
Sex:
Male
Male
Female
Age:
1 weeks
1 weeks
2 weeks
3 weeks
4 weeks
5 weeks
6 weeks
7 weeks
8 weeks
9 weeks
10 weeks
11 weeks
12 weeks
13 weeks
14 weeks
15 weeks
16 weeks
17 weeks
18 weeks
19 weeks
20 weeks
21 weeks
22 weeks
23 weeks
24 weeks
25 weeks
26 weeks
27 weeks
28 weeks
29 weeks
30 weeks
>30 weeks
Genotype:
(Ldlr)KO/KO
(Ldlr)KO/KO
Submit Inquiry
BASIC INFORMATION
Strain Name:
C57BL/6JGpt-
Ldlr
em1Cd82
/Gpt
Strain Number:
T001464
Official Symbol:
Ldlr
Strain Strategy:
T001464.Ldlr-KO Strategy-EN.pdf
T001464.LDL-R-KO strain info.pdf
Official Full Name:
low density lipoprotein receptor
Also Known As:
Hlb301
NCBI Number:
16835
MGI Number:
96765
Chromosome:
9
Deletion (size):
-82bp
Research Areas:
Disease Models,Cardiovascular Disease,Atherosclerosis,Hyperlipidemia
Strain Background:
[N000013] C57BL/6JGpt
Modification Type:
Knockout (KO)
Inventory Status:
Live,Cryopreserved
Sale Status:
IF (Available for Distribution)
Health Status:
Specific pathogen free (SPF)
Health Report:
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Publications:
1. Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.
Food & Function
(2021)
2. Aberrant oligodendroglial LDL receptor orchestrates demyelination in chronic cerebral ischemia.
The Journal of clinical investigation
(2021)
3. circGNAQ, a Circular RNA Enriched in Vascular Endothelium, Inhibits Endothelial Cell Senescence and Atherosclerosis Progression.
Molecular Therapy-Nucleic Acids
(2021)
4. Exendin-4 attenuates atherosclerosis progression via controlling hematopoietic stem/progenitor cell proliferation.
J Mol Cell Biol
(2023)
5. Tanshinone IIA alleviates atherosclerosis in LDLR(-/-) mice by regulating efferocytosis of macrophages.
Front Pharmacol
(2023)
6. Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cbeta/store-operated calcium entry/calreticulin/scavenger receptor A pathways.
Eur Heart J
(2023)
7. LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus.
Cell Res
(2024)
8. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
Nature
(2022)
9. A gut-derived hormone regulates cholesterol metabolism.
Cell
(2024)
10. Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor.
Cell Death Dis
(2024)
11. siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice.
Journal of Lipid Research
(2024)
Gene Family:
Low density lipoprotein receptors
MicroRNA protein coding host genes
0
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