Accelerating Innovation, One Mouse Model at a Time

Genetically engineered mouse models (GEMMs) are essential tools for investigating gene function, understanding disease mechanisms, and evaluating therapeutic hypotheses. Yet, generating a custom mouse model involves multiple stages, from genetic strategy and genome editing to genotyping, breeding, and validation.

In this eBook, developed in collaboration with BioCompare, explore the science behind knockout and conditional knockout models, common challenges in model generation, and how specialized CROs can support researchers throughout the process.

Download Accelerating Innovation, One Mouse Model at a Time to explore practical approaches to custom GEMM development and the role of specialized CROs in supporting the process.

Complete the form on the right to access your complimentary copy.

WHAT YOU'LL LEARN

Explore the Science and Process Behind Custom Mouse Model Generation

This eBook brings together scientific insights and practical perspectives on genetically engineered mouse models, including:

01. The Power of Gene Knockouts

Understand the scientific rationale behind conventional and conditional knockout models and their applications in studying gene function, disease mechanisms, and therapeutic targets.

02. Challenges in Custom Model Generation

Explore common challenges associated with GEMM development, including gene editing efficiency, embryonic lethality, breeding difficulties, and unintended phenotypic effects.

03. How CROs Support Model Development

Learn how specialized CROs can provide end-to-end support, from target selection and genetic design to genome editing, genotyping, breeding, and model delivery.

04. Expanding Access Through Large-Scale Model Collections

Discover how initiatives such as GemPharmatech's Knockout All Project (KOAP) are expanding access to ready-to-use knockout and conditional knockout models.

WHY GEMPHARMATECH?

Comprehensive GEMM Solutions to Support Your Research

From custom model development to ready-to-use mouse strains, GemPharmatech provides integrated genetically engineered mouse model solutions to support biomedical research and drug discovery.

Our capabilities include:

• 30,000+ Mouse Models

  Access a searchable catalog of more than 30,000 mouse models, covering a broad range of genetic modifications and research applications.

• 22,000+ KO and Conditional KO Models

  Explore our Knockout All Project (KOAP), which currently includes more than 22,000 mouse strains and aims to generate knockout and conditional knockout models targeting nearly 23,000 protein-coding genes in the mouse genome.

• End-to-End Custom Model Generation

  Receive support throughout the model development process, including target selection, genetic strategy design, genome editing, genotyping, breeding, and validation.

• Extensive Genome Editing Expertise

• Leverage our technical capabilities in complex genetic modifications, including knockout, conditional knockout, knock-in, and transgenic model generation.