In Vivo Drug Efficacy Evaluation

List of Mouse Models for Neurological Diseases


Neurological Disease

Model Name

Model Number

Model Type

Alzheimer's Disease (AD) Models

FAD2T(APP/PS1)

T005625

Transgenic

FAD3T(APP/PS1/Tau)

T049751

Transgenic

FAD4T

T053302

Transgenic

Humanized Alzheimer's Disease (AD) Models

FAD4T-hTREM2

T058996

Transgenic

FAD4T-hAPOE3

T065022

Transgenic

FAD4T-hAPOE4

T064971

Transgenic

Parkinson's Disease (PD) Models

hSNCA A53T

T054329

Transgenic

hSNCA E46KA53T  

T054322

Transgenic

B6-Tfam-flox/Slc6a3-Cre

T053276

Transgenic

6-OHDA-induced PD model

/

Induced

Huntington's Disease (HD) Models

hHTT CAG130-N

T054804

Transgenic

Amyotrophic Lateral Sclerosis (ALS) Models

hSOD1G93A

T055223

Transgenic

hTDP43wtxA315T

T054620

Transgenic

Transthyretin Amyloidosis (ATTR) Models

hTTR KI

T055186

Knock in

hTTR V30M Tg

T059897

Transgenic

hTTR V30M Tg:ttr KO

T059956

Transgenic

Duchenne Muscular Dystrophy (DMD) Models

B10-Dmd-KO

T003035

Knock out

Dmd C3197T

T014593

Point Mutation

B6-Dmd Del45

T056002

Knock out

B6-Dmd Del50

T056003

Knock out

B6-Dmd Del51

T056004

Knock out

B6-Dmd Del52

T049591

Knock out

Delivering Therapeutics Across the Blood-Brain Barrier (BBB) --Transferrin receptor

B6-hTFRC

T067796

Knock in

FAD4T-h/m TFRC

T065962

Transgenic

FAD3T-h/m TFRC

T065963

Transgenic

Pain Mouse Models

Inflammatory Pain

Formalin-induced Acute Inflammatory Pain

/

Induced

Complete Freund's Adjuvant(CFA)-induced Mechanical Allodynia

/

Induced

Neuropathic pain

Sciatic nerve crush

/

Induced

Chemotherapy-induced Peripheral Neuropathy

Vincristine-Induced Peripheral Neuropathy

/

Induced

Oxaliplatin-Induced Peripheral Neuropathy

/

Induced

Paclitaxel-Induced Peripheral Neuropathy

/

Induced

Diabetic Peripheral Neuropathy

MLDS-induced Diabetic Peripheral Neuropathy

/

Induced

Migraine

Nitroglycerin-induced Migraine-like Pain

/

Induced


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