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Oncology

Development of Preclinical Models for the Evaluation of Conventional and in vivo CAR-T Therapies

2025-05-01

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Traditional CAR-T therapies depend on costly, labor-intensive ex vivo engineering of patient- or donor-derived T cells. Recent innovations in in vivo CAR-T generation—using lentiviral vectors to directly program T cells within the body—promise a faster, more economical alternative. However, preclinical testing of these strategies requires immunodeficient mouse models expressing human-specific targets, which are frequently hindered by graft-versus-host disease (GvHD), shortening treatment windows and confounding results.


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