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C57BL/6JGpt-H11em1Cin(K18-hACE2)/Gpt
H11-K18-hACE2|Strain
NO.T037657
Knockin(KI)
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C57BL/6JGpt-H11em1Cin(K18-hACE2)/Gpt
H11-K18-hACE2|Strain
NO.T037657
Knockin(KI)
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C57BL/6JGpt-H11em1Cin(K18-hACE2)/Gpt
H11-K18-hACE2|Strain
NO.T037657
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C57BL/6JGpt-H11em1Cin(K18-hACE2)/Gpt
H11-K18-hACE2|Strain
NO.T037657
Knockin(KI)
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周 龄
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- 基本信息
- 基因官方名：ACE2,H11
- 基因全名：angiotensin I converting enzyme 2
- 基因别名：ACEH,hACE2
- NCBI：59272
- 染色体：Chr 11
- 销售状态：IF(正常销售)
- 保存方式： 活体,冷冻
- 品系背景：[N000013] C57BL/6JGpt
- 微生物等级： SPF级
- 品系策略： 登录后查看品系策略，点我登录
- 品系策略： T037657.H11-K18-hACE2 strain info.pdf T037657.H11-K18-hACE2 品系资料.pdf T037657.H11-K18-hACE2 Strategy.pdf
- 研究领域：人源化模型,基因人源化模型
- 领域描述：1.SARS-CoV-2的机制研究;2.SARS-CoV-2的疫苗或者抑制剂药效及安全性评价;3.自身免疫病研究;4.新冠疾病相关。
- 发表文献：
Development of highly effective LCB1-based lipopeptides targeting the spike receptor-binding motif of SARS-CoV-2 https://doi.org/10.1016/j.antiviral.2023.105541 Recombinant chimpanzee adenovirus vector vaccine expressing the spike protein provides effective and lasting protection against SARS-CoV-2 infection in mice https://doi.org/10.1016/j.virs.2022.05.006 Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone https://doi.org/10.1038/s41392-022-00981-5 SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration https://doi.org/10.1038/s41392-021-00719-9 Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics https://doi.org/10.1038/s41467-021-25153-x Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenza https://doi.org/10.1038/s41392-021-00618-z Coinfection with influenza A virus enhances SARS-CoV-2 infectivity https://doi.org/10.1038/s41422-021-00473-1 SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19 https://doi.org/10.1186/s13045-020-00954-7 A combination vaccine against SARS-CoV-2 and H1N1 influenza based on receptor binding domain trimerized by six-helix bundle fusion core http://doi.org/10.1016/j.ebiom.2022.104297 In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2 https://doi.org/10.1016/j.antiviral.2022.105450 NSUN2-mediated M(5)c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections https://doi.org/10.1080/22221751.2023.2178238 Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2 https://doi.org/10.1073/pnas.2202820120 Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and nonhuman primates https://doi.org/10.1126/sciadv.adg3277 Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis https://doi.org/10.1038/s41392-023-01438-z
*使用本品系发表的文献需注明：H11-K18-hACE2 mice（Strain NO.T037657）were purchased from GemPharmatech (Nanjing, China).
