Humanized Alzheimer's Disease (AD) Models

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by an insidious onset and progressive development. The primary clinical features of the disease include progressive memory impairment, cognitive decline, executive dysfunction, as well as accompanying language disorders, motor function impairment, personality changes, and neuropsychiatric symptoms.

Most existing AD mouse models are constructed by introducing APP gene mutations carried by familial AD patients. However, familial AD patients account for less than 5% of clinical AD cases, with the majority of AD patients having sporadic AD and not carrying familial AD mutations. Therefore, by introducing multiple sporadic AD-related risk genes, such as TREM2 and APOE4, into the FAD4T model, it is possible to better simulate the disease phenotypes of sporadic AD patients.

GemPharmatech has developed three humanized AD models that can be utilized for the screening and safety evaluation of Alzheimer's disease treatments.