CDX模型(Cell line-derived xenograft model)是将人源的肿瘤细胞移植到小鼠的皮下,用于药效学评价或者肿瘤相关科学研究,是目前抗肿瘤药物临床前药效学评价最常用的体内模型之一。
集萃药康拥有包括胰腺癌、乳腺癌、结肠癌、肺癌、淋巴癌在内的多种CDX模型。可满足多种药效实验需求。
Cancer types(number of cell lines) | name of cell lines |
Bladder | UM-UC-3, HT1376, RT4, T24 |
Human bladder carcinoma epithelial | RT112/84 |
Brain | U251, U-87 MG |
Breast | BT-20, BT-474, BT-549, HCC1937, HCC1954, HCC1569, Hs 578T, JIMT-1, MCF7, MDA-MB-175VII, |
Colorectal | Colo205, HCT-116, HT29, HT-55, LoVo, LS174T, RKO, SW48 |
Carcinoma; Colorectal; Dukes' type C | Ls1034 |
Dukes' type C, grade III, colorectal adenocarcinoma | SW948 |
Adenocarcinoma; Colorectal; Dukes' type B | SW480 |
Colon adenocarcinoma | COLO-320 |
Duodenal | HuTu 80 |
tongue squamous cell carcinoma | Cal 27 |
Leukemia | HL-60, Jurkat, K562, MOLT-4, MV-4-11, Nalm-6, SUP-B15, THP-1, CCRF-CEM, Hut78, TF1, Hs 505.T |
acute myeloid leukemia | MOLM13, OCIAML3 |
NSCLC | A549, HCC-827, NCI-H1703, NCI-H1755, NCI-H1975, NCI-H2122, NCI-H358, NCI-H460, NCI-H1299, NCI-H647 |
SCLC | DMS-53, NCI-2171, NCI-H446, NCI-H526, NCI-H82, SHP-77 |
Carcinoma; Mucoepidermoid Pulmonary | NCI-H226, NCI-H292, NCI-H727, NCI-H69 |
Ademocarcimoma | Calu-3, NCI-H1666, NCI-H441,NCI-H1650 |
melanoma | A375, COLO829, SK-MEL-28, SK-MEL-5 |
Multiple Myeloma | NCI-H929, MM.1R, MOLP-8, RPMI-8226, MM.1S |
Ovary | OVCAR-3, SK-OV-3, TOV-112D |
teratocarcinoma | PA-1 |
clear cell carcinoma | Es-2 |
Pancreas | AsPC-1, BxPC-3, CAPAN-1, CFPAC-1, HPAC, MIA PaCa-2, PANC-1, SW1990 |
Prostate | 22RV1, LNCaP, PC-3, LNCaP C4-2B |
Renal | ACHN, 786-O |
Sarcoma | HT1080, SJSA-1, U-2 OS |
Skin | A431 |
Lymphoma | U937, NK92, Jeko-1, Daudi, Ramos, JVM-2, KAPPAS 299, Raj, SU-DHL-10, SU-DHL-16, U-2932, L-540 |
Liver | HepG2, Huh7 |
Gastric | Hs 746T, MKN45, NCI-N87, SGC-7901, SNU-16, KATOIII, NUGC4 |
Neuroblastoma | IMR-32, SK-N-BE(2) |
submandibular adenosquamous carcinoma | A253 |
Endometrial carcinoma | HEC-1-A |
Squamous Cell Carcinoma | FaDu |
Chondrosarcoma | SW1353 |
Esophagus | KYSE-150 |
Barett adenocarcinoma | OE33 |
Carcinoma;Anaplastic | Calu-6 |
Myeloma; plasmacytoma | U-266 |
Osteosarcoma | MG63 |
Cancer types | Cell lines-luc |
Leukemia | Nalm6-Luc |
Lymphoma | Raji-Luc |
Melanoma | A375-Luc |
Multiple myeloma | RPMI8226-Luc |
Liver cancer | Huh7-Luc |
Colon cancer | HT-29-Luc |
Glioblastoma | U251-Luc |
Lung cancer | A549-Luc |
Pancreatic cancer | PANC-Luc |
Breast cancer | MDA-MB-468-Luc |
Ovarian cancer | SKOV3-Luc |
Uterine cancer | HEC-1-A-Luc |