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B6/JGpt-Lepem1Cd25/Gpt
B6-ob|Strain
NO.T001461
Knockout (KO)
- 性别： --
- 周龄： --
- 基因型： --
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B6/JGpt-Lepem1Cd25/Gpt
B6-ob|Strain
NO.T001461
Knockout (KO)
性 别
周 龄
基因型
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- 基本信息
- 销售状态：IF(正常销售)
- 保存方式： 活体,冷冻
- 品系背景：[N000013] C57BL/6JGpt
- 微生物等级： SPF级
- 品系策略： 登录后查看品系策略，点我登录
- 品系策略： T001461.Lep Cas9-KO Strategy-EN.pdf T001461.B6-ob strain Info.pdf T001461.B6-ob 品系资料.pdf
- 研究领域：代谢研究,脂肪组织,蛋白质代谢,糖代谢,内稳态/代谢,脂代谢,发育生物学,细胞分化,胚胎,增长/尺寸/体型,死亡/衰老,免疫系统,肿瘤研究,神经系统,视力/眼睛,行为/神经,生理系统,皮肤,心血管系统,骨骼系统,肌肉,呼吸系统,生殖系统,消化系统,肝脏/胆道系统,肾和泌尿系统,内/外分泌腺,造血系统,四肢/尾巴,细胞生物学,细胞增殖,细胞死亡,细胞组成,细胞定位,分子生物学,信号转导,DNA转录,DNA结合蛋白,疾病与药物评价模型,代谢模型,糖尿病模型,肥胖模型
- 领域描述：1、肥胖症研究及肥胖治疗药物非临床评价;2、研究“瘦素”的信号通路;3、生殖生理研究。
- 发表文献：
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity https://doi.org/10.1016/j.cmet.2021.02.007 Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo https://doi.org/10.1002/advs.202000818 Hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and their mechanisms https://doi.org/10.1039/C9FO02283J Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse model https://doi.org/10.1016/j.lfs.2020.118966 Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging https://doi.org/10.1021/acs.analchem.1c00498 Immunotherapy against angiotensin II receptor ameliorated insulin resistance in a leptin receptor‐dependent manner https://doi.org/10.1096/fj.202000300R Dahuang Fuzi Baijiang decoction restricts progenitor to terminally exhausted T cell differentiation in colorectal cancer https://doi.org/10.1111/cas.15311 MicroRNA-21 promotes pancreatic beta cell function through modulating glucose uptake https://doi.org/10.1038/s41467-022-31317-0 Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer https://doi.org/10.1002/advs.202203357
*使用本品系发表的文献需注明：B6-ob mice（Strain NO.T001461）were purchased from GemPharmatech (Nanjing, China).
