Myasthenia Gravis

Autoimmune Nephropathy Models and Efficacy Services
IgA NephropathyC3 GlomerulonephritisLupus NephritisMembranous Nphropathy
Asthma Models and Efficacy Services
HDM induced asthma modelsOVA inudced asthma models
Systemic Lupus Erythematosus (SLE) Models and Efficacy Services
Spontaneous SLE ModelsInduction SLE ModelsImmune Reconstitution SLE Models
Sjögren's Syndrome Models and Efficacy Services
Salivary Gland Protein Induced Sjögren's Syndrome Mouse ModelSTING Agonist Induced Sjögren’s Syndrome Mouse Model
Neuroimmune Diseases Models and Efficacy Services
Multiple Sclerosis (MS) ModelsMyasthenia Gravis (MG) Models
Autoimmune Dermatoses Models and Efficacy Services
Psoriasis ModelsAtopic DermatitisAlopecia Areata (AA)Vitiligo ModelsSclerodermaUrticaria
Inflammatory Bowel Disease (IBD) Models and Efficacy Services
DSS Induced IBD ModelAdaptive T cell Transfer IBD ModelImmune Reconstitution IBD ModelAnti-CD40 Induced Colitis Models
Rheumatoid Arthritis (RA) Models and Efficacy Services
Collagen Induced Arthritis ModelCollagen Antibody Induced Arthritis ModelImmune Reconstitution Arthritis ModelmBSA induced Induced DTHA Model
Immune Reconstitution Autoimmune Disease Models and Efficacy Services
SLEIBDArthritisMyasthenia GravisPassive Cutaneous AnaphylaxisPassive Systemic Anaphylaxis (PSA)

Myasthenia gravis (MG) is an autoimmune disease characterized by ptosis, fatigue, and muscle weakness, caused by the association of pathogenic autoantibodies with postsynaptic membrane proteins at neuromuscular junctions. Eighty percent to 90% of cases are mediated by antibodies directed against the acetylcholine receptor (AChR).

 

Strategy of  patient derived PBL-NCG MG Model


Peripheral blood lymphocytes (PBLs) derived from MG patients were infused into NCG (strain No.T001475) mice to generate a MG disease model.


3.jpeg


Igs levels in serum

 

4.png

The level of anti-human AChR antibody and human IgG in the serum increased in model group G2.

 

Limb grip test and pathohistological study

 


5.png


 

7.jpeg

8.jpeg

A decrease in limb grip was observed with a corresponding increase in the HE score of Tibialis anterior and gastrocnemius muscle within the model group.