Immune Reconstitution Arthritis Model

Autoimmune Nephropathy Models and Efficacy Services
IgA NephropathyC3 GlomerulonephritisLupus NephritisMembranous Nphropathy
Asthma Models and Efficacy Services
HDM induced asthma modelsOVA inudced asthma models
Systemic Lupus Erythematosus (SLE) Models and Efficacy Services
Spontaneous SLE ModelsInduction SLE ModelsImmune Reconstitution SLE Models
Sjögren's Syndrome Models and Efficacy Services
Salivary Gland Protein Induced Sjögren's Syndrome Mouse ModelSTING Agonist Induced Sjögren’s Syndrome Mouse Model
Neuroimmune Diseases Models and Efficacy Services
Multiple Sclerosis (MS) ModelsMyasthenia Gravis (MG) Models
Autoimmune Dermatoses Models and Efficacy Services
Psoriasis ModelsAtopic DermatitisAlopecia Areata (AA)Vitiligo ModelsSclerodermaUrticaria
Inflammatory Bowel Disease (IBD) Models and Efficacy Services
DSS Induced IBD ModelAdaptive T cell Transfer IBD ModelImmune Reconstitution IBD ModelAnti-CD40 Induced Colitis Models
Rheumatoid Arthritis (RA) Models and Efficacy Services
Collagen Induced Arthritis ModelCollagen Antibody Induced Arthritis ModelImmune Reconstitution Arthritis ModelmBSA induced Induced DTHA Model
Immune Reconstitution Autoimmune Disease Models and Efficacy Services
SLEIBDArthritisMyasthenia GravisPassive Cutaneous AnaphylaxisPassive Systemic Anaphylaxis (PSA)

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects millions of individuals worldwide. This debilitating condition primarily targets the joints, causing pain, swelling, morning stiffness, and irreversible damage if left uncontrolled.

 

Adjuvant-induced HSC-NCG-M


Human hematopoietic stem cells (HSCs) were infused into NCG-M (strain No.T036669) mice, the immune-deficient mice, to reconstitute human immune cell population, followed by administration of CFA to induce arthritis.

 

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Arthritis score

 

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CFA administration caused paw swelling and increased the arthritis score.

 

Immune cell population in synovial fluid

 

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Expansion of T cells and myeloid cells in CFA induced immune reconstitution arthritis model.

 

Pathohistological study

 

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Articular inflammation, bone erosion and proteoglycans damage were observed in arthritis model.

 

Drug efficacy studies

 

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Adalimumab significantly alleviated the claw swelling, while tocilizumab exhibited no obvious efficacy.