Membranous Nphropathy

Autoimmune Nephropathy Models and Efficacy Services
IgA NephropathyC3 GlomerulonephritisLupus NephritisMembranous Nphropathy
Asthma Models and Efficacy Services
HDM induced asthma modelsOVA inudced asthma models
Systemic Lupus Erythematosus (SLE) Models and Efficacy Services
Spontaneous SLE ModelsInduction SLE ModelsImmune Reconstitution SLE Models
Sjögren's Syndrome Models and Efficacy Services
Salivary Gland Protein Induced Sjögren's Syndrome Mouse ModelSTING Agonist Induced Sjögren’s Syndrome Mouse Model
Neuroimmune Diseases Models and Efficacy Services
Multiple Sclerosis (MS) ModelsMyasthenia Gravis (MG) Models
Autoimmune Dermatoses Models and Efficacy Services
Psoriasis ModelsAtopic DermatitisAlopecia Areata (AA)Vitiligo ModelsSclerodermaUrticaria
Inflammatory Bowel Disease (IBD) Models and Efficacy Services
DSS Induced IBD ModelAdaptive T cell Transfer IBD ModelImmune Reconstitution IBD ModelAnti-CD40 Induced Colitis Models
Rheumatoid Arthritis (RA) Models and Efficacy Services
Collagen Induced Arthritis ModelCollagen Antibody Induced Arthritis ModelImmune Reconstitution Arthritis ModelmBSA induced Induced DTHA Model
Immune Reconstitution Autoimmune Disease Models and Efficacy Services
SLEIBDArthritisMyasthenia GravisPassive Cutaneous AnaphylaxisPassive Systemic Anaphylaxis (PSA)

Membranous nephropathy (MN) is a kidney disorder characterized by thickening of the glomerular basement membrane in the kidney’s filtering units (glomeruli). It is a leading cause of nephrotic syndrome (proteinuria, hypoalbuminemia, edema, hyperlipidemia) in adults. It can occur as a primary (idiopathic) disease or secondary to other conditions (e.g., autoimmune diseases, infections, cancers, or medications).


To help with your MN preclinical study, we are offering a validated model of MN induced by cationic bovine serum albumin (c-BSA).

 


cBSA induced MN


In c-BSA has been demonstrated to play a pathogenetic role in some cases of childhood membranous nephropathy, suggesting a link to environmental agents such as food. Furthermore, intravenous injection of cationic bovine serum albumin (c-BSA) into mice can cause lesions typical of the disease.


11.png


Fig 1.Characterization of cBSA induced Membranous nephropathy. A, Model strategy: cBSA in an optimum dose was given intravenously to 8-week-old female BALB/c; B, UACR was significant raised in week 6 and week 8 after cBSA induction; C, By week 8, the IgA deposition was observed in MN kindey; D, histology study of MN kidney by H&E; Thickening of basement membrane of renal corpuscle (↑); Renal tubular atrophy (↑) ; Lymphocyte (↑)；Fibrous tissue hyperplasia (↑). Data presented as mean ± SEM. *P<0.05，**P<0.01；***P<0.001.

 


Data request in progress, please wait…