HDM induced asthma models

Model Establishment


  • Experimental mouse strains: BALB/c, Female

  • Modeling reagent: HDM

  • Dosing route: Intranasal instillation


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Efficacy Study: Duplilumab


  • Experimental mouse strains: B6-hIL-4/hIL-4Ra mice, Female

  • Modeling reagent: HDM

  • Dosing route: Intranasal instillation


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The administration of Duplilumab decreased serum levels of IgE and IL-4 in the HDM-induced asthma model. In addition, less PAS staining of lung tissue were observed in Duplilumab treated animals compared with G1 vehicle group. Data is expressed as Mean ± SEM. Statistics performed using One way ANOVA. ***: P<0.001; ****: P<0.0001. G1: Vehicle; G2: 25mpk Dupilumab; G3: 25mpk test article (TA)

 

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The administration of Duplilumab to HDM-induced asthmatic mice ameliorated the cell counts of eosinophils and interstitial macrophages in the lung tissue while only ameliorating the cell counts of eosinophils in circulating lung blood. G1: Vehicle; G2: 25mpk Dupilumab; G3: 25mpk test article (TA). Data is expressed as Mean ± SEM. Statistical analysis wa performed using one-way ANOVA. *P<0.05,***: P<0.001; ****: P<0.0001.

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