HDM induced asthma models

Autoimmune Nephropathy Models and Efficacy Services
IgA NephropathyC3 GlomerulonephritisLupus NephritisMembranous Nphropathy
Asthma Models and Efficacy Services
HDM induced asthma modelsOVA inudced asthma models
Systemic Lupus Erythematosus (SLE) Models and Efficacy Services
Spontaneous SLE ModelsInduction SLE ModelsImmune Reconstitution SLE Models
Sjögren's Syndrome Models and Efficacy Services
Salivary Gland Protein Induced Sjögren's Syndrome Mouse ModelSTING Agonist Induced Sjögren’s Syndrome Mouse Model
Neuroimmune Diseases Models and Efficacy Services
Multiple Sclerosis (MS) ModelsMyasthenia Gravis (MG) Models
Autoimmune Dermatoses Models and Efficacy Services
Psoriasis ModelsAtopic DermatitisAlopecia Areata (AA)Vitiligo ModelsSclerodermaUrticaria
Inflammatory Bowel Disease (IBD) Models and Efficacy Services
DSS Induced IBD ModelAdaptive T cell Transfer IBD ModelImmune Reconstitution IBD ModelAnti-CD40 Induced Colitis Models
Rheumatoid Arthritis (RA) Models and Efficacy Services
Collagen Induced Arthritis ModelCollagen Antibody Induced Arthritis ModelImmune Reconstitution Arthritis ModelmBSA induced Induced DTHA Model
Immune Reconstitution Autoimmune Disease Models and Efficacy Services
SLEIBDArthritisMyasthenia GravisPassive Cutaneous AnaphylaxisPassive Systemic Anaphylaxis (PSA)

Model Establishment


  • Experimental mouse strains: BALB/c, Female

  • Modeling reagent: HDM

  • Dosing route: Intranasal instillation


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Efficacy Study: Duplilumab


  • Experimental mouse strains: B6-hIL-4/hIL-4Ra mice, Female

  • Modeling reagent: HDM

  • Dosing route: Intranasal instillation


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The administration of Duplilumab decreased serum levels of IgE and IL-4 in the HDM-induced asthma model. In addition, less PAS staining of lung tissue were observed in Duplilumab treated animals compared with G1 vehicle group. Data is expressed as Mean ± SEM. Statistics performed using One way ANOVA. ***: P<0.001; ****: P<0.0001. G1: Vehicle; G2: 25mpk Dupilumab; G3: 25mpk test article (TA)

 

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The administration of Duplilumab to HDM-induced asthmatic mice ameliorated the cell counts of eosinophils and interstitial macrophages in the lung tissue while only ameliorating the cell counts of eosinophils in circulating lung blood. G1: Vehicle; G2: 25mpk Dupilumab; G3: 25mpk test article (TA). Data is expressed as Mean ± SEM. Statistical analysis wa performed using one-way ANOVA. *P<0.05,***: P<0.001; ****: P<0.0001.

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