Custom Mouse Model Generation Services
CRO with Gene Editing, Knockout, Knock-In, and Transgenic Mouse Model Capabilities
▎Research-Ready Custom Mouse Models
GemPharmatech provides custom mouse model generation services for researchers in academia, pharma, biotech, and CRO partners worldwide. Our platforms support rapid creation of knockout (KO), conditional knockout (cKO), knock-in (KI), point-mutation (PM), and transgenic mouse models used in preclinical research, target validation, and therapeutic development.
GemPharmatech delivers three guaranteed F1 heterozygous mice suitable for immediate breeding and study, helping research teams save months in development timelines.
Why Use a CRO like GemPharmatech for Custom Mouse Models?
Scientists should consider custom model generation when existing models do not reflect the biological mechanism of interest, as well as numerous scientific and bugetary concerns. When choosing a partner, there are clear benefits to working with a CRO that has produced the most genetically engineered mouse models in the world:
Ability to create over 6000 new models each year
Multi-gene and multi-locus editing capability
Wide selection of genetic backgrounds
Proven experience supporting global CRO and pharma programs
Experienced in numerous therapeutic areas
▎What Is Custom Mouse Model Generation?
Custom mouse model generation uses advanced gene editing and genetic engineering technologies to introduce precise modifications into the mouse genome. These models allow researchers to study gene function, disease mechanisms, and drug targets in vivo.
Working with an experienced creator of custom models like GemPharmatech, you can have confidence that the method of your model production aligns with your end-goals.
▎Our Gene Editing and Model Generation Platforms
1. Gene Editing Technology for KO, cKO, PM, and KI Models
Our primary platform for knockout and knock-in mouse model generation.
Advantages
High editing efficiency
Faster timelines compared with traditional methods
Cost-effective model development
Supports simultaneous modification of multiple loci
This approach is ideal for most gene knockout, conditional knockout, point-mutation, and knock-in projects.
2. ES Cell Homologous Recombination
Embryonic Stem (ES) cell targeting is used for complex gene modifications and large DNA insertions.
Advantages:
Suitable for large or complex genetic edits
BAC targeting supports large DNA fragment integration
Established and proven platform
Supports multiple genetic backgrounds
This method is recommended when edits exceed the capabilities of standard gene editing approaches.
3. Transgenic Mouse Model Technology
Transgenic approaches are typically used for gene overexpression or conditional expression models. DNA is integrated into the mouse genome to generate models expressing genes of interest under specific promoters or regulatory elements.
▎Types of Genetically Engineered Mouse Models
1. Knockout (KO) and Conditional Knockout (cKO) Models
KO Strategy
CKO Strategy
2. Knock-In (KI) Mouse Models
KI Strategy
3. Point-Mutation (PM) Mouse Models
PM Strategy
4. Transgenic (TG) Mouse Models
With a 100% success rate, BAC transgenic technology supports the customization of transgenic models exceeding 300kb.
TG Strategy
▎Our Certifications
▎Capabilities
45, 000+m SPF Facilities
300, 000+ SPF Cage Capacity
▎Frequently Asked Questions
1. How long does custom mouse model generation take?
Timelines depend on model type and complexity but are optimized using high-efficiency platforms.
2. Do you deliver F0 or F1 animals?
GemPharmatech delivers F1 generation mice to reduce downstream development time.
3. Can multiple genes be modified in one model?
Yes. Our platforms support multi-locus and multi-gene editing strategies.
4. What genetic backgrounds are available?
Multiple commonly used inbred and specialized backgrounds are supported.
▎Start Your Custom Mouse Model Project
Contact GemPharmatech to discuss your target gene, model design, and timeline requirements.