Cholestasis Models
Obesity ModelsDiabetes ModelsAndrogenetic Alopecia (AGA) ModelsMASH ModelsChronic Liver Fibrosis ModelsAcute Liver Injury ModelsChronic Kindey Disease (CKD) ModelsCholestasis ModelsAlcohol-related Liver Disease (ALD) ModelsActue Kindey Disease (AKD) ModelsDiabetes Nephropathy (Diabetic Kidney Disease) ModelsOsteoporosis ModelsSarcopenia ModelsGout/Hyperuricemia ModelsFemale Reproduction Models
Hemophilia ModelsProgressive Familial Intrahepatic Cholestasis ModelsAutosomal Dominant Polycystic Kidney Disease (ADPKD)Glycogen Storage Disease type 1a ModelGrowth Failure ModelsFabry Disease ModelsHepatolenticular Degeneration ModelNiemann-Pick Disease (Sphingomyelinosis) ModelsHypophosphatasia ModelGM2 Gangliosidoses ModelPulmonary Alveolar Proteinosis ModelLimb Girdle Muscular Dystrophies ModelMaple Syrup Urine Disease ModelMucopolysaccharidosis ModelsHutchinson-Gilford Progeria Syndrome ModelPhenylketonuria/Hyperphenylalaninemia ModelsUrea Cycle Disorders ModelsTyrosinemia ModelThalassemia Models
Cholestasis is a liver disorder defined by disrupted bile flow. Bile, crucial for digestion and waste elimination, can be affected either within the liver (intrahepatic cholestasis) or due to blockages in external bile ducts (extrahepatic cholestasis). Its causes vary widely, encompassing genetic mutations, certain medications, liver diseases like primary biliary cholangitis, as well as gallstones, tumors, and inflammation. When bile accumulates, it damages liver cells, manifesting as symptoms like jaundice, itching, dark urine, and pale stools. If left untreated, cholestasis can progress to severe conditions such as cirrhosis and liver failure, highlighting the importance of prompt diagnosis and appropriate management.