Imaging and Analysis Platform

Custom Model Generation Services
Preclinical Testing Services
Anti-Tumor Drug Efficacy EvaluationAutoimmune Disease Efficacy EvaluationMetabolic Disease Efficacy EvaluationNeurological Disease Efficacy EvaluationCardiovascular Diseases Efficacy EvaluationBioanalytical ServicesPhenotyping ServicesNon-GLP Toxicity Assessment ServicesCell Therapy & Gene Therapy Efficacy EvaluationDisease Rat Models Infectious Disease Efficacy Evaluation
Germ-Free and Microbiome Services
Mouse-Derived Gut Microbiota LibraryCustomized Germ-free ServicesEvaluation of Anti-tumor Effect of Gut MicrobiotaMicrobiota Extraction and TransplantationGerm-free Rederivation and BreedingMicrobial Strain Culture and Colonization
Cell Lines and Customization Services
Cell Line Customization ServicesSyngeneic Cell LinesReporter Cell LinesCDX Cell Lines
Patient Derived Xenograft (PDX) Mouse Models and Efficacy Services
Custom Breeding Services
Customized Mice Breeding ServicesCryopreservation and ResuscitationAssisted ReproductionMouse Rederivation Service
Animal Quality Testing Services
SNP Testing ServicesMicrobiology Testing ServicesGenetic IntegrityAnimal HealthAnimal Welfare
NeoMab Fully-Human Antibody Discovery Service
Assay Capabilities
Molecular PlatformPK/PD PlatformPathological Diagnosis PlatformCell-based Service PlatformFlow Cytometry PlatformImaging and Analysis PlatformBehavioral Analysis Platform
Other Services
Animal Facility and HusbandryReproductive and Embryology Services Isolation of Embryonic Fibroblasts

The GemPharmatech Imaging and Analysis Platform is equipped with a dual-energy X-ray absorptiometry and an in vivo optical imaging system. The dual-energy X-ray absorptiometry provides high-resolution X-ray imaging for assessing bone density and body composition in live animals and ex-vivo tissues, primarily accommodating model organisms such as  mice and rats. It's used for research on diseases such as osteoporosis, obesity, metabolic disorders, and aging.

 

The in vivo optical imaging system at GPT offers high-quality fluorescence and bioluminescence imaging capabilities, enabling tracking and detection of labeled cell and gene activities in vivo. It's also used for studying the distribution, metabolism, targeting, and accumulation of luminescent substances such as fluorescent probes, novel luminescent materials, and labeled drugs in vivo.


Service Offering


(1) Dual-Energy X-ray Absorptiometry


The system utilizes high-energy and low-energy X-rays to calculate body composition by measuring the differential attenuation within the examined body. It provides high-resolution X-ray scan images used to measure whole-body or local bone density, as well as fat and lean tissue content in experimental animals.

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(2) In vivo Optical Imaging System


The in vivo optical imaging system collects and analyzes light signals, enabling quantitative monitoring of tumor growth, metastasis, drug distribution, and other physiological signals  in mice. This system facilitates drug efficacy evaluation and detection of drug distribution.

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GPT Advantages


(1) Dual-Energy X-ray Absorptiometry


  • Precise bone density detection

  • Safe and convenient

  • Reliable  data

  • High image quality

 

(2) In Vivo Optical Imaging System


  • Large field of view

  • High throughput

  • Multimodal imaging

  • Absolute quantitative analysis


Case Studies


(1)  Dual-Energy X-ray Absorptiometry: can export X-ray images, bone mineral density images, and pseudo-colored body composition images

  • X-ray images (for measuring partial bone length, determining fractures, and locating implants using high-resolution images).

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  • BMD  Images

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  • Body composition images (reflecting the distribution and changes in body composition, with red indicating fat distribution)

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  • Isolated bone tissue

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(2) In Vivo Optical Imaging System


Drug distribution experiment: Four mice were treated with a fluorescence-labeled drug, while the fifth served as a control.

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