Cell-based Service Platform
Gene editing is a genetic engineering technique that enables precise modifications, such as knockouts, insertions, and specific point mutations, to target genes or their transcription products. This is primarily achieved through artificial nucleases, which allow for specific gene sequence knockout, insertion, or precision editing within the genome. The CRISPR-Cas9 system can be used to knock out or overexpress certain genes, making it a valuable tool for screening target genes. When combined with relevant functional assays, it can identify key target genes essential for specific biological processes or diseases.
GPT has a refined CRISPR-Cas9 system that offers higher editing efficiency and lower off-target effects. We offer a wide range of gene editing services, including gene knockout, gene knock-in, gene overexpression, and modifications with luciferase, among others. Depending on the unique characteristics of different cells, we choose the most suitable transfection or infection methods, such as lipid transfection, electroporation, or lentiviral infection.
- CRISPR Gene Editing Cell Lines
- Luciferase Modified Cell Lines
- Mouse Derived Cell Lines
- CDX
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Cell Line Engineering
Gene editing is a precise genetic engineering method that involves modifying target genes or their transcription products using artificial nucleases, such as the CRISPR-Cas9 system. This technique allows for knockouts, insertions, and specific point mutations within the genome. The CRISPR-Cas9 system can be used to manipulate gene expression and has valuable applications in screening target genes for specific biological processes or diseases. GPT offers an advanced CRISPR-Cas9 system with enhanced editing efficiency and reduced off-target effects, providing various gene editing services, including knockout, knock-in, overexpression, and luciferase modifications, tailored to different cell characteristics using suitable transfection or infection methods.
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In vitro Pharmacological Evaluation
In vitro drug efficacy evaluation is a crucial step in preclinical research for drug development, especially for large molecule antibodies, ADCs, nucleic acid-based drugs, and small molecules. GPT's cellular service platform offers professional and customized drug efficacy evaluation plans for these diverse drug types. Integrated with our in vitro drug efficacy analysis platform, we provide a one-stop, comprehensive preclinical assessment.
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Tumor-bearing Mouse Models
GPT possesses a vast collection of immune-deficient strains and target humanized strains on both C57BL/6 and BALB/c backgrounds, coupled with an extensive resource of tumor cell lines. We offer tumor efficacy services using a variety of wild-type and humanized cells for both subcutaneous and orthotopic tumor studies. Furthermore, we supply a significant number of mouse models with commonly used human cell lines for subcutaneous tumor xenograft studies. By leveraging our comprehensive tumor induction data and robust experimental systems, we ensure that our customers receive stable and reliable oncology mouse models.